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学科主题: 公共卫生
题名:
A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat
作者: Liang, Jiang1,2; Pei, Xin-Rong1; Zhang, Zhao-Feng1; Wang, Nan1; Wang, Jun-Bo1; Li, Yong1
关键词: marine collagen peptides ; chronic oral toxicity ; Sprague-Dawley rat
刊名: MARINE DRUGS
发表日期: 2012
DOI: 10.3390/md10010020
卷: 10, 期:1, 页:20-34
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: FISH ; CARCINOGENICITY ; CHOLESTEROL ; SCALES ; LIVER ; BONE
英文摘要:

Due to the increased consumption of marine collagen peptides preparation (MCP) as ingredients in functional foods and pharmaceuticals, it was necessary to carry out safety requirements in the form of an oral chronic toxicity assessment. In order to define the oral chronic toxicity of MCP, a 24-month feeding study of MCP was carried out. Sprague-Dawley (S-D) rats at the age of four-week of both sexes were treated with MCP at the diet concentrations of 0%, 2.25%, 4.5%, 9% and 18% (wt/wt). The actual food intake and bodyweight of the individual animals were recorded periodically until sacrifice. Blood and urine samples were collected for serum chemistry evaluations and urinalysis. Throughout the experimental period, there was no toxicologically significant difference between the vehicle and MCP-treated animals with respect to the survival rate, body weight, food consumption, urinalysis, clinical biochemistry parameter and relative organ weight in either sex. Moreover, incidences of non-neoplastic lesions in MCP-treated groups did not significantly increase compared with the control group. Under the present experimental conditions, no higher risk of chronic toxic effects was observed in MCP-treated rats at the diet concentrations of 2.25%, 4.5%, 9% and 18% (wt/wt) than in the rats fed with basal rodent diet.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000299541800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50041
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
2.Chinese Ctr Dis Control & Prevent, Inst Nutr & Food Safety, Beijing 100050, Peoples R China

Recommended Citation:
Liang, Jiang,Pei, Xin-Rong,Zhang, Zhao-Feng,et al. A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat[J]. MARINE DRUGS,2012,10(1):20-34.
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