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A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat
Liang, Jiang1,2; Pei, Xin-Rong1; Zhang, Zhao-Feng1; Wang, Nan1; Wang, Jun-Bo1; Li, Yong1
关键词Marine Collagen Peptides Chronic Oral Toxicity Sprague-dawley Rat
刊名MARINE DRUGS
2012
DOI10.3390/md10010020
10期:1页:20-34
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]FISH ; CARCINOGENICITY ; CHOLESTEROL ; SCALES ; LIVER ; BONE
英文摘要

Due to the increased consumption of marine collagen peptides preparation (MCP) as ingredients in functional foods and pharmaceuticals, it was necessary to carry out safety requirements in the form of an oral chronic toxicity assessment. In order to define the oral chronic toxicity of MCP, a 24-month feeding study of MCP was carried out. Sprague-Dawley (S-D) rats at the age of four-week of both sexes were treated with MCP at the diet concentrations of 0%, 2.25%, 4.5%, 9% and 18% (wt/wt). The actual food intake and bodyweight of the individual animals were recorded periodically until sacrifice. Blood and urine samples were collected for serum chemistry evaluations and urinalysis. Throughout the experimental period, there was no toxicologically significant difference between the vehicle and MCP-treated animals with respect to the survival rate, body weight, food consumption, urinalysis, clinical biochemistry parameter and relative organ weight in either sex. Moreover, incidences of non-neoplastic lesions in MCP-treated groups did not significantly increase compared with the control group. Under the present experimental conditions, no higher risk of chronic toxic effects was observed in MCP-treated rats at the diet concentrations of 2.25%, 4.5%, 9% and 18% (wt/wt) than in the rats fed with basal rodent diet.

语种英语
WOS记录号WOS:000299541800002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50041
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
2.Chinese Ctr Dis Control & Prevent, Inst Nutr & Food Safety, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Liang, Jiang,Pei, Xin-Rong,Zhang, Zhao-Feng,et al. A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat[J]. MARINE DRUGS,2012,10(1):20-34.
APA Liang, Jiang,Pei, Xin-Rong,Zhang, Zhao-Feng,Wang, Nan,Wang, Jun-Bo,&Li, Yong.(2012).A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat.MARINE DRUGS,10(1),20-34.
MLA Liang, Jiang,et al."A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat".MARINE DRUGS 10.1(2012):20-34.
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