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学科主题: 临床医学
题名:
Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction
作者: Shan, Zhi-Xin1; Lin, Qiu-Xiong1; Fu, Yong-Heng1; Deng, Chun-Yu1; Zhou, Zhi-Ling1; Zhu, Jie-Ning1; Liu, Xiao-Ying1; Zhang, You-Yi4; Li, Yangxin2,3; Lin, Shu-Guang1; Yu, Xi-Yong1
关键词: MicroRNAs ; Ischemia ; Myocardial infarction ; Gene expression ; IGF-1 ; Apoptosis ; Serum deprivation ; Hypoxia
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-04-17
DOI: 10.1016/j.bbrc.2009.02.097
卷: 381, 期:4, 页:597-601
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: MUSCLE-SPECIFIC MICRORNA ; APOPTOSIS ; DIFFERENTIATION ; CONNEXIN-43 ; CARDIOMYOCYTES ; MIR-1 ; IGF-1
英文摘要:

MicroRNAs (miRNAs) have been increasingly reported to have important roles in diverse biological and pathological processes. We investigated miR-1 and miR-206 expression and their potential roles in a rat model of myocardial infarction (MI). miR-1 and miR-206 expression were significantly increased, and insulin-like growth factor 1 (IGF-1) protein was markedly reduced without obvious change of its mRNA level after MI induction. Position 175-196 of rat IGF-1 3′-untranslated region was identified to be required for efficient downregulation by miR-1/miR-206. IGF-1 level was reduced without changing its transcript level in rat H9C2 myoblast cells modified with miR-1 (H9C2-miR-1). In the serum withdrawal and hypoxic condition, caspase-3 activity and mitochondrial potential were significantly increased in H9C2-miR-1 cells compared with the control group, respectively (p < 0.05, p < 0.01). Together, our results indicate that miR-1 and miR-206 are involved in apoptotic cell death in MI by post-transcriptional repression of IGF-1. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30672077 ; 30772142 ; 2006CB503806
项目资助者: National Natural Science Foundation of China ; National Key Basic Research Program (NKBRP) of China
WOS记录号: WOS:000264929400028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50046
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Guangdong Acad Med Sci, Guangdong Prov Cardiovasc Inst, Res Ctr Guangdong Gen Hosp, Guangzhou 510080, Guangdong, Peoples R China
2.Univ Texas Hlth Sci Ctr, Houston, TX 77030 USA
3.Texas Heart Inst, Houston, TX 77030 USA
4.Peking Univ, Inst Vasc Med, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Shan, Zhi-Xin,Lin, Qiu-Xiong,Fu, Yong-Heng,et al. Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,381(4):597-601.
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