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学科主题基础医学
Reduced expression of ASS is closely related to clinicopathological features and post-resectional survival of hepatocellular carcinoma
Yang, Hua1; Lin, Ming1; Xiong, Fu Xia1; Yang, Yu2; Nie, Xiu3; Zhou, Rou Li1
关键词Arginosuccinate Synthetase Immunohistochemistry Hepatocellular Carcinoma Survival
刊名ONCOLOGY LETTERS
2010
DOI10.3892/ol_00000005
1期:1页:31-36
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ARGININE DEIMINASE TREATMENT ; ARGININOSUCCINATE SYNTHETASE ; IN-VITRO ; DEPRIVATION ; CANCER ; CYCLE ; VIVO
英文摘要

Argininosuccinate synthetase (ASS) has previously been proven to be reductively expressed in hepatocellular carcinoma (HCC) and various types of HCC cell lines Arginine, the product of ASS, has been used as a target in HCC by recombinant human arginase or arginine deiminase, which is now in the phase II clinical trial stage This study aimed to present the levels of ASS expression in HCCs and its correlation with clinicopathological features and prognosis of HCC patients Immunohistochemical detection of ASS was performed on samples from 71 patients with HCC Positive staining was found in 21 HCCs, with a score of 2, as well as in normal liver tissues Reduced ASS staining was found in 70 4% (50/71) of HCC tissues, including 21 with a score of 0 and 29 with a score of 1 The staining score in cancer tissues was significantly associated with gender, background liver, histopathological differentiation, recurrence, TNM staging and portal vein invasion (P < 0 05), but not with age, viral status, tumor size and serum alpha-fetoprotein level Patients with a high ASS expression had significantly poorer overall and disease-free survival (P < 0 001 and P < 0 001, respectively) These data showed that ASS was reductively or negatively expressed in a large portion of HCC, and that ASS levels in HCCs correlated inversely with prognosis In conclusion, a high expression of ASS may be a novel marker of poor prognosis of patients presenting with HCC

语种英语
WOS记录号WOS:000284562300005
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50056
专题基础医学院_细胞生物学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China
3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pathol, Wuhan 430074, Peoples R China
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Yang, Hua,Lin, Ming,Xiong, Fu Xia,et al. Reduced expression of ASS is closely related to clinicopathological features and post-resectional survival of hepatocellular carcinoma[J]. ONCOLOGY LETTERS,2010,1(1):31-36.
APA Yang, Hua,Lin, Ming,Xiong, Fu Xia,Yang, Yu,Nie, Xiu,&Zhou, Rou Li.(2010).Reduced expression of ASS is closely related to clinicopathological features and post-resectional survival of hepatocellular carcinoma.ONCOLOGY LETTERS,1(1),31-36.
MLA Yang, Hua,et al."Reduced expression of ASS is closely related to clinicopathological features and post-resectional survival of hepatocellular carcinoma".ONCOLOGY LETTERS 1.1(2010):31-36.
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