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学科主题: 口腔医学
题名:
Synergistic cytotoxic action of vitamin C and vitamin K-3
作者: Zhang, W1; Negoro, T1; Satoh, K1; Jiang, J1; Hashimoto, K1; Kikuchi, H1; Nishikawa, H1; Miyata, T1; Yamamoto, Y1; Nakano, K1; Yasumoto, E1; Nakayachi, T1; Mineno, K1; Satoh, T1; Sakagami, H1
关键词: vitamin C ; vitamin K-3 ; oral tumor cells ; cytotoxicity ; mechanism
刊名: ANTICANCER RESEARCH
发表日期: 2001-09-01
卷: 21, 期:5, 页:3439-3444
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: RADICAL INTENSITY ; ANTITUMOR-ACTIVITY ; SODIUM ASCORBATE ; CELLS ; ANTIOXIDANTS ; APOPTOSIS
英文摘要:

We investigated the combination effect of sodium ascorbate (vitamin Q and menadione (vitamin K-3) on the viability of various cultured cells. Human oral squamous cell carcinoma (HSC-2, HSC-3) and human promyelocytic leukemia (HL-60) cells were more sensitive to these vitamins as compared to normal cells (human gingival fibroblast HGF, human periodontal ligament fibroblast HPLF, human pulp cell HPC). The combination of vitamin C and vitamin K-3 produced synergistic cytotoxicity against all these 6 cell lines. Treatment with vitamin C or vitamin K-3, or their combination, induced internucleosomal DNA fragmentation only in HL-60 cells, but not in the oral tumor cell lines (HSC-2, HSC-3, HSG). ESR spectroscopy showed that vitamins C and K-3 produce radicals under alkaline conditions and that the combination of these two vitamins synergistically enhanced their respective radical intensities.

语种: 英语
WOS记录号: WOS:000173740400042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50061
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Meikai Univ, Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283, Japan
2.Meikai Univ, Sch Dent, Meikai Pharmaco Med Lab, Sakado, Saitama 3500283, Japan
3.Meikai Univ, Sch Dent, Dept Endodont, Sakado, Saitama 3500283, Japan
4.Meikai Univ, Sch Dent, Dept Periodontol, Sakado, Saitama 3500283, Japan
5.Meikai Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Sakado, Saitama 3500283, Japan
6.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100038, Peoples R China
7.Showa Univ, Sch Pharmaceut Sci, Anal Ctr, Tokyo 1428555, Japan

Recommended Citation:
Zhang, W,Negoro, T,Satoh, K,et al. Synergistic cytotoxic action of vitamin C and vitamin K-3[J]. ANTICANCER RESEARCH,2001,21(5):3439-3444.
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