IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Synergistic cytotoxic action of vitamin C and vitamin K-3
Zhang, W1; Negoro, T1; Satoh, K1; Jiang, J1; Hashimoto, K1; Kikuchi, H1; Nishikawa, H1; Miyata, T1; Yamamoto, Y1; Nakano, K1; Yasumoto, E1; Nakayachi, T1; Mineno, K1; Satoh, T1; Sakagami, H1
关键词Vitamin c Vitamin K-3 Oral Tumor Cells Cytotoxicity Mechanism
刊名ANTICANCER RESEARCH
2001-09-01
21期:5页:3439-3444
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]RADICAL INTENSITY ; ANTITUMOR-ACTIVITY ; SODIUM ASCORBATE ; CELLS ; ANTIOXIDANTS ; APOPTOSIS
英文摘要

We investigated the combination effect of sodium ascorbate (vitamin Q and menadione (vitamin K-3) on the viability of various cultured cells. Human oral squamous cell carcinoma (HSC-2, HSC-3) and human promyelocytic leukemia (HL-60) cells were more sensitive to these vitamins as compared to normal cells (human gingival fibroblast HGF, human periodontal ligament fibroblast HPLF, human pulp cell HPC). The combination of vitamin C and vitamin K-3 produced synergistic cytotoxicity against all these 6 cell lines. Treatment with vitamin C or vitamin K-3, or their combination, induced internucleosomal DNA fragmentation only in HL-60 cells, but not in the oral tumor cell lines (HSC-2, HSC-3, HSG). ESR spectroscopy showed that vitamins C and K-3 produce radicals under alkaline conditions and that the combination of these two vitamins synergistically enhanced their respective radical intensities.

语种英语
WOS记录号WOS:000173740400042
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50061
专题北京大学口腔医学院
作者单位1.Meikai Univ, Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283, Japan
2.Meikai Univ, Sch Dent, Meikai Pharmaco Med Lab, Sakado, Saitama 3500283, Japan
3.Meikai Univ, Sch Dent, Dept Endodont, Sakado, Saitama 3500283, Japan
4.Meikai Univ, Sch Dent, Dept Periodontol, Sakado, Saitama 3500283, Japan
5.Meikai Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Sakado, Saitama 3500283, Japan
6.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100038, Peoples R China
7.Showa Univ, Sch Pharmaceut Sci, Anal Ctr, Tokyo 1428555, Japan
推荐引用方式
GB/T 7714
Zhang, W,Negoro, T,Satoh, K,et al. Synergistic cytotoxic action of vitamin C and vitamin K-3[J]. ANTICANCER RESEARCH,2001,21(5):3439-3444.
APA Zhang, W.,Negoro, T.,Satoh, K.,Jiang, J.,Hashimoto, K.,...&Sakagami, H.(2001).Synergistic cytotoxic action of vitamin C and vitamin K-3.ANTICANCER RESEARCH,21(5),3439-3444.
MLA Zhang, W,et al."Synergistic cytotoxic action of vitamin C and vitamin K-3".ANTICANCER RESEARCH 21.5(2001):3439-3444.
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