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学科主题: 药学
题名:
A class of novel Schiff′s bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis
作者: Zhou, Yinjian2; Zhao, Ming1; Wu, Yingting1; Li, Chunyu1; Wu, Jianhui1; Zheng, Meiqing1; Peng, Li1; Peng, Shiqi1,2
关键词: Shiff&prime ; s base ; Analgesic ; Anti-inflammation ; 3D QSAR equation
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
发表日期: 2010-03-15
DOI: 10.1016/j.bmc.2010.01.075
卷: 18, 期:6, 页:2165-2172
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: ANTIINFLAMMATORY ACTIVITY ; BIOLOGICAL EVALUATION ; METAL-COMPLEXES ; DERIVATIVES ; ANTIBACTERIAL ; ANTIFUNGAL ; INHIBITORS ; COUMARIN ; DESIGN
英文摘要:

To discover analgesics for treating chronic pain 17 novel Schiff′s bases, N,N′-(Z-allylidene-1,3-diyl)bisamino acid methyl esters were prepared from 1,1,3,3,-tetramethoxypropane and amino acid methyl esters. On tail-flick mouse model 20 mu mol/kg of these Schiff′s bases were orally administered, the analgesic action started 30 min after administration, reached the maximum 120 min after administration, and at 180 min this action was still observed. On a xylene-induced ear edema mouse model 20 mu mol/kg of these Schiff′s bases exhibited desirable anti-inflammation. Thus the present Schiff′s bases are able to treat chronic pain from inflammation. The effect of the side chains of the amino acid residues of these Schiff′s bases on the analgesic activity was explained with 3D QSAR. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: IHLB: KZ 2008100250-10 ; 200910025004 ; 2008ZX09401-002 ; 30672513 ; 20772082
项目资助者: PHR ; Special Project ; Natural Scientific Foundation of China
WOS记录号: WOS:000275513700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50062
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100069, Peoples R China
2.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, Yinjian,Zhao, Ming,Wu, Yingting,et al. A class of novel Schiff′s bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(6):2165-2172.
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