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A class of novel Schiff′s bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis
Zhou, Yinjian2; Zhao, Ming1; Wu, Yingting1; Li, Chunyu1; Wu, Jianhui1; Zheng, Meiqing1; Peng, Li1; Peng, Shiqi1,2
关键词Shiff&Prime s Base Analgesic Anti-inflammation 3d Qsar Equation
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2010-03-15
DOI10.1016/j.bmc.2010.01.075
18期:6页:2165-2172
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ANTIINFLAMMATORY ACTIVITY ; BIOLOGICAL EVALUATION ; METAL-COMPLEXES ; DERIVATIVES ; ANTIBACTERIAL ; ANTIFUNGAL ; INHIBITORS ; COUMARIN ; DESIGN
英文摘要

To discover analgesics for treating chronic pain 17 novel Schiff′s bases, N,N′-(Z-allylidene-1,3-diyl)bisamino acid methyl esters were prepared from 1,1,3,3,-tetramethoxypropane and amino acid methyl esters. On tail-flick mouse model 20 mu mol/kg of these Schiff′s bases were orally administered, the analgesic action started 30 min after administration, reached the maximum 120 min after administration, and at 180 min this action was still observed. On a xylene-induced ear edema mouse model 20 mu mol/kg of these Schiff′s bases exhibited desirable anti-inflammation. Thus the present Schiff′s bases are able to treat chronic pain from inflammation. The effect of the side chains of the amino acid residues of these Schiff′s bases on the analgesic activity was explained with 3D QSAR. (C) 2010 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000275513700013
项目编号IHLB: KZ 2008100250-10 ; 200910025004 ; 2008ZX09401-002 ; 30672513 ; 20772082
资助机构PHR ; Special Project ; Natural Scientific Foundation of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50062
专题北京大学药学院
作者单位1.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100069, Peoples R China
2.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Yinjian,Zhao, Ming,Wu, Yingting,et al. A class of novel Schiff′s bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(6):2165-2172.
APA Zhou, Yinjian.,Zhao, Ming.,Wu, Yingting.,Li, Chunyu.,Wu, Jianhui.,...&Peng, Shiqi.(2010).A class of novel Schiff′s bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis.BIOORGANIC & MEDICINAL CHEMISTRY,18(6),2165-2172.
MLA Zhou, Yinjian,et al."A class of novel Schiff′s bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis".BIOORGANIC & MEDICINAL CHEMISTRY 18.6(2010):2165-2172.
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