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Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani
Ma, Xiao-Chi1; Zheng, Jian1; Guo, De-An1
关键词Biotransformation Resibufogenin Cinobufagin Bufalin Fusarium Solani
刊名ENZYME AND MICROBIAL TECHNOLOGY
2007-05-02
DOI10.1016/j.enzmictec.2006.11.015
40期:6页:1585-1591
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]HUMAN LEUKEMIA-CELLS ; MICROBIAL HYDROXYLATION ; MUCOR-SPINOSUS ; ANIMAL ORIGIN ; BUFALIN ; CINOBUFAGIN ; RESIBUFOGENIN ; 12-BETA-HYDROXYLATION ; BIOTRANSFORMATION ; DIFFERENTIATION
英文摘要

Twenty strains of filamentous fungi (from nine genera) and four species of bacteria were screened for their capabilities to transform bufadienolides. The highly stereo- and regiospecific isomerization and dehydrogenation of three major bufadienolides (resibufogenin, cinobufagin and bufalin) at 3-OH by Fusarium solani AS 3.1829 were reported. Three major transformed products were obtained and their structures were identified as 3-epi-resibufogenin (1a), 3-epi-bufalin (2a), 3-keto-cinobufagin (3a), respectively, on the basis of their spectral data. The reaction kinetics and the effects of pH, substrate concentration and incubation phase on the biotransformation were also investigated. (C) 2006 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000246312500020
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50064
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学第二临床医学院_党委院长办公室
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Natl Inst Control Biol & Pharmaceut Prod, Beijing 100050, Peoples R China
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Ma, Xiao-Chi,Zheng, Jian,Guo, De-An. Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani[J]. ENZYME AND MICROBIAL TECHNOLOGY,2007,40(6):1585-1591.
APA Ma, Xiao-Chi,Zheng, Jian,&Guo, De-An.(2007).Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani.ENZYME AND MICROBIAL TECHNOLOGY,40(6),1585-1591.
MLA Ma, Xiao-Chi,et al."Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani".ENZYME AND MICROBIAL TECHNOLOGY 40.6(2007):1585-1591.
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