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VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients
Zhang, YS; Zhang, HG; Fu, Y; Song, HS; Wang, LP; Zhang, J; Fan, DS
关键词Amyotrophic Lateral Sclerosis Vascular Endothelial Growth Factor C2578a Polymorphism
刊名AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS
2006-06-01
DOI10.1080/14660820600600657
7期:2页:119-122
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; FACTOR GENE ; SUPEROXIDE-DISMUTASE ; MODIFIER GENE ; PROMOTER ; SURVIVAL ; DELETION ; MICE ; ALS ; MUTATION
英文摘要

A linkage and association of the VEGF (vascular endothelial growth factor) C2578A polymorphism and amyotrophic lateral sclerosis (ALS) has been found in some studies. We analysed the C2578A polymorphism in sporadic ALS patients from a Chinese population. The polymorphism was analysed in 115 patients and 200 healthy individuals by amplifying across position 2705 to 2494 of the promoter region of the VEGF gene. It was found that the frequency of the allele A was 24% in ALS patients and 28% in healthy individuals (p=0.264). Comparing the background of this polymorphism in healthy individuals between Chinese and Caucasians, significant decreases were found in the frequencies of the A/A genotype and allele A(p(s) <0.001). We concluded that VEGF C2578A polymorphism did not confer a susceptibility to sporadic Chinese ALS patients, which was in disagreement with that reported previously in Caucasian populations and might be ascribed to the different genetic background between Chinese and Caucasians.

语种英语
WOS记录号WOS:000238196200009
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50068
专题北京大学第三临床医学院_神经内科
作者单位Peking Univ, Hosp 3, Dept Neurol, Beijing 100083, Peoples R China
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Zhang, YS,Zhang, HG,Fu, Y,et al. VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients[J]. AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS,2006,7(2):119-122.
APA Zhang, YS.,Zhang, HG.,Fu, Y.,Song, HS.,Wang, LP.,...&Fan, DS.(2006).VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients.AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS,7(2),119-122.
MLA Zhang, YS,et al."VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients".AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS 7.2(2006):119-122.
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