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学科主题: 临床医学
题名:
VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients
作者: Zhang, YS; Zhang, HG; Fu, Y; Song, HS; Wang, LP; Zhang, J; Fan, DS
关键词: amyotrophic lateral sclerosis ; vascular endothelial growth factor ; C2578A polymorphism
刊名: AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS
发表日期: 2006-06-01
DOI: 10.1080/14660820600600657
卷: 7, 期:2, 页:119-122
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; FACTOR GENE ; SUPEROXIDE-DISMUTASE ; MODIFIER GENE ; PROMOTER ; SURVIVAL ; DELETION ; MICE ; ALS ; MUTATION
英文摘要:

A linkage and association of the VEGF (vascular endothelial growth factor) C2578A polymorphism and amyotrophic lateral sclerosis (ALS) has been found in some studies. We analysed the C2578A polymorphism in sporadic ALS patients from a Chinese population. The polymorphism was analysed in 115 patients and 200 healthy individuals by amplifying across position 2705 to 2494 of the promoter region of the VEGF gene. It was found that the frequency of the allele A was 24% in ALS patients and 28% in healthy individuals (p=0.264). Comparing the background of this polymorphism in healthy individuals between Chinese and Caucasians, significant decreases were found in the frequencies of the A/A genotype and allele A(p(s) <0.001). We concluded that VEGF C2578A polymorphism did not confer a susceptibility to sporadic Chinese ALS patients, which was in disagreement with that reported previously in Caucasian populations and might be ascribed to the different genetic background between Chinese and Caucasians.

语种: 英语
WOS记录号: WOS:000238196200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50068
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Neurol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, YS,Zhang, HG,Fu, Y,et al. VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients[J]. AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS,2006,7(2):119-122.
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