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学科主题: 临床医学
题名:
Functional Investigation on Aromatase in Endometrial Hyperplasia in Polycystic Ovary Syndrome Cases
作者: Zhao, Pan-Lin1,2; Zhang, Qiu-Fang1; Yan, Li-Ying1; Huang, Shuo1; Chen, Yuan1; Qiao, Jie1
关键词: Polycystic ovary syndrome ; endometrial hyperplasia ; aromatase P450 ; letrozole ; testosterone
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2014
DOI: 10.7314/APJCP.2014.15.20.8975
卷: 15, 期:20, 页:8975-8979
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CANCER ; EXPRESSION ; CARCINOMA ; LETROZOLE ; GENE ; PROLIFERATION ; POLYMORPHISMS ; ANASTROZOLE ; INHIBITORS ; CYP19A1
英文摘要:

Objective: To explore the possible significance of aromatase P450 in endometrial hyperplasia with a background of polycystic ovary syndrome (PCOS). Methods: Immunohistochemistry was used to determine the expression of aromatase P450 in endometrium of PCOS patients. Semiquantitative analysis of aromatase P450 expression of mRNA and protein level was also carried out by real-time quantitative RT-PCR method. After endometrial cells were stimulated by testosterone and letrozole in vitro, the estradiol (E-2) level was determined, and the expression of cell aromatase P450 mRNA was assessed. Results: The aromatase P450 mRNA level was increased in endometria of PCOS patients. When endometrial cells were cultured with 10(-6) M testosterone, the E-2 level in the culture medium increased. An inhibitory effect on E2 generation and expression of aromatase P450 mRNA was observed when the endometrial cells were treated with 10(-5) M letrozole. Conclusions: There is an increased expression of aromatase P450 in PCOS patient endometrium. Androgen stimulation could enhance the synthesis of aromatase P450 mRNA and the production of E-2 in endometrial cells in vitro while letrozole could do the reverse.

语种: 英语
WOS记录号: WOS:000351055100076
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50069
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Reprod Ctr, Hosp 3, Beijing 100871, Peoples R China
2.PLA, Airforce Gen Hosp, Reprod Ctr, Beijing, Peoples R China

Recommended Citation:
Zhao, Pan-Lin,Zhang, Qiu-Fang,Yan, Li-Ying,et al. Functional Investigation on Aromatase in Endometrial Hyperplasia in Polycystic Ovary Syndrome Cases[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(20):8975-8979.
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