IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Functional Investigation on Aromatase in Endometrial Hyperplasia in Polycystic Ovary Syndrome Cases
Zhao, Pan-Lin1,2; Zhang, Qiu-Fang1; Yan, Li-Ying1; Huang, Shuo1; Chen, Yuan1; Qiao, Jie1
关键词Polycystic Ovary Syndrome Endometrial Hyperplasia Aromatase P450 Letrozole Testosterone
刊名ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
2014
DOI10.7314/APJCP.2014.15.20.8975
15期:20页:8975-8979
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER ; EXPRESSION ; CARCINOMA ; LETROZOLE ; GENE ; PROLIFERATION ; POLYMORPHISMS ; ANASTROZOLE ; INHIBITORS ; CYP19A1
英文摘要

Objective: To explore the possible significance of aromatase P450 in endometrial hyperplasia with a background of polycystic ovary syndrome (PCOS). Methods: Immunohistochemistry was used to determine the expression of aromatase P450 in endometrium of PCOS patients. Semiquantitative analysis of aromatase P450 expression of mRNA and protein level was also carried out by real-time quantitative RT-PCR method. After endometrial cells were stimulated by testosterone and letrozole in vitro, the estradiol (E-2) level was determined, and the expression of cell aromatase P450 mRNA was assessed. Results: The aromatase P450 mRNA level was increased in endometria of PCOS patients. When endometrial cells were cultured with 10(-6) M testosterone, the E-2 level in the culture medium increased. An inhibitory effect on E2 generation and expression of aromatase P450 mRNA was observed when the endometrial cells were treated with 10(-5) M letrozole. Conclusions: There is an increased expression of aromatase P450 in PCOS patient endometrium. Androgen stimulation could enhance the synthesis of aromatase P450 mRNA and the production of E-2 in endometrial cells in vitro while letrozole could do the reverse.

语种英语
WOS记录号WOS:000351055100076
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50069
专题北京大学第三临床医学院
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Reprod Ctr, Hosp 3, Beijing 100871, Peoples R China
2.PLA, Airforce Gen Hosp, Reprod Ctr, Beijing, Peoples R China
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GB/T 7714
Zhao, Pan-Lin,Zhang, Qiu-Fang,Yan, Li-Ying,et al. Functional Investigation on Aromatase in Endometrial Hyperplasia in Polycystic Ovary Syndrome Cases[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(20):8975-8979.
APA Zhao, Pan-Lin,Zhang, Qiu-Fang,Yan, Li-Ying,Huang, Shuo,Chen, Yuan,&Qiao, Jie.(2014).Functional Investigation on Aromatase in Endometrial Hyperplasia in Polycystic Ovary Syndrome Cases.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(20),8975-8979.
MLA Zhao, Pan-Lin,et al."Functional Investigation on Aromatase in Endometrial Hyperplasia in Polycystic Ovary Syndrome Cases".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.20(2014):8975-8979.
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