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In vivo studies on the oridonin-loaded nanostructured lipid carriers
Zheng, Dandan1; Dai, Wenting2; Zhang, Dianrui1; Duan, Cunxian1; Jia, Lejiao1; Liu, Yue1; Zhang, Qiang3
关键词Oridonin Nanostructured Lipid Carriers Intravenous Administration Biodistribution Pharmacokinetics
刊名DRUG DELIVERY
2012-08-01
DOI10.3109/10717544.2012.704096
19期:6页:286-291
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TISSUE DISTRIBUTION ; NANOPARTICLES SLN ; DELIVERY-SYSTEM ; DRUG-DELIVERY ; CELL-CYCLE ; PHARMACOKINETICS ; BIOAVAILABILITY ; NANOSUSPENSION ; EFFICACY ; RELEASE
英文摘要

Oridonin (ORI)-loaded Nanostructured lipid carriers (NLC) were prepared by emulsion-evaporation and low temperature-solidification technique, and evaluated for morphological observation, particle size, zeta potential and in vitro drug release. Next, the characteristics of biodistribution and pharmacokinetics in vivo were examined. The average particle size of resultant NLC was 245.2 nm and the zeta potential was found to be -38.77 mV. The in vivo characteristics of ORI-loaded NLC were studied after intravenous administration using Kunming strain mice as experimental animals. An ORI control solution was studied parallelly. In tested organs, the distribution of ORI-loaded NLC to liver was higher than that of free drug. ORI-loaded NLC showed higher AUC (area under tissue concentration-time curve) values and circulated in the blood stream for a longer time compared with ORI solution. These results support the potential applications of NLC for the delivery of ORI.

语种英语
WOS记录号WOS:000308724500002
项目编号2009CB930 300 ; 30472130
资助机构National Basic Research Program of China (973 Program) ; National Nature Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50070
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250100, Peoples R China
2.Second Peoples Hosp Hefei, Dept Pharm, Hefei, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Dandan,Dai, Wenting,Zhang, Dianrui,et al. In vivo studies on the oridonin-loaded nanostructured lipid carriers[J]. DRUG DELIVERY,2012,19(6):286-291.
APA Zheng, Dandan.,Dai, Wenting.,Zhang, Dianrui.,Duan, Cunxian.,Jia, Lejiao.,...&Zhang, Qiang.(2012).In vivo studies on the oridonin-loaded nanostructured lipid carriers.DRUG DELIVERY,19(6),286-291.
MLA Zheng, Dandan,et al."In vivo studies on the oridonin-loaded nanostructured lipid carriers".DRUG DELIVERY 19.6(2012):286-291.
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