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学科主题: 药学
题名:
In vivo studies on the oridonin-loaded nanostructured lipid carriers
作者: Zheng, Dandan1; Dai, Wenting2; Zhang, Dianrui1; Duan, Cunxian1; Jia, Lejiao1; Liu, Yue1; Zhang, Qiang3
关键词: Oridonin ; Nanostructured lipid carriers ; intravenous administration ; biodistribution ; pharmacokinetics
刊名: DRUG DELIVERY
发表日期: 2012-08-01
DOI: 10.3109/10717544.2012.704096
卷: 19, 期:6, 页:286-291
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TISSUE DISTRIBUTION ; NANOPARTICLES SLN ; DELIVERY-SYSTEM ; DRUG-DELIVERY ; CELL-CYCLE ; PHARMACOKINETICS ; BIOAVAILABILITY ; NANOSUSPENSION ; EFFICACY ; RELEASE
英文摘要:

Oridonin (ORI)-loaded Nanostructured lipid carriers (NLC) were prepared by emulsion-evaporation and low temperature-solidification technique, and evaluated for morphological observation, particle size, zeta potential and in vitro drug release. Next, the characteristics of biodistribution and pharmacokinetics in vivo were examined. The average particle size of resultant NLC was 245.2 nm and the zeta potential was found to be -38.77 mV. The in vivo characteristics of ORI-loaded NLC were studied after intravenous administration using Kunming strain mice as experimental animals. An ORI control solution was studied parallelly. In tested organs, the distribution of ORI-loaded NLC to liver was higher than that of free drug. ORI-loaded NLC showed higher AUC (area under tissue concentration-time curve) values and circulated in the blood stream for a longer time compared with ORI solution. These results support the potential applications of NLC for the delivery of ORI.

语种: 英语
所属项目编号: 2009CB930 300 ; 30472130
项目资助者: National Basic Research Program of China (973 Program) ; National Nature Science Foundation of China
WOS记录号: WOS:000308724500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50070
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250100, Peoples R China
2.Second Peoples Hosp Hefei, Dept Pharm, Hefei, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Zheng, Dandan,Dai, Wenting,Zhang, Dianrui,et al. In vivo studies on the oridonin-loaded nanostructured lipid carriers[J]. DRUG DELIVERY,2012,19(6):286-291.
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