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学科主题: 药学
题名:
Biotransformation of 20(S)-protopanaxadiol by Mucor spinosus
作者: Li, Huifeng1; Ye, Min1,3; Guo, Hongzhu1,2; Tian, Yin1; Zhang, Jie1; Zhou, Jianping2; Hu, Yuchi2; Guo, Dean1,3
关键词: Biotransformation ; Dehydrogenation ; Hydroxylation ; Mucor spinosus AS 3.3450 ; 20(S)-Protopanaxadiol
刊名: PHYTOCHEMISTRY
发表日期: 2009-07-01
DOI: 10.1016/j.phytochem.2009.07.041
卷: 70, 期:11-12, 页:1416-1420
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: GINSENG ; GINSENOSIDES ; SAPOGENINS ; SAPONINS ; LEUKEMIA
英文摘要:

Biotransformation of 20(S)-protopanaxadiol (1) by the fungus Mucor spinosus AS 3.3450 yielded eight metabolites (2-9). On the basis of NMR and MS analyses, the metabolites were identified as 12-oxo-15 alpha,27-dihydroxyl-20(S)-protopanaxadiol (2), 12-oxo-7 beta,11 alpha,28-trihydroxyl-20(S)-protopanaxadiol (3), 12-oxo-7 beta,28-dihydroxyl-20(S)-protopanaxadiol (4), 12-oxo-15 alpha,29-dihydroxyl-20(S)-protopanaxadiol (5), 12-oxo-7 beta,15 alpha-dihydroxyl-20(S)-protopanaxadiol (6), 12-oxo-7 beta,11 beta-dihydroxyl-20(S)-protopanaxadiol (7), 12-oxo-15 alpha-hydroxyl-20(S)-protopanaxadiol (8), and 12-oxo-7 beta-hydroxyl-20(S)-protopanaxadiol (9), respectively. Among them, 2-5, 7, and 8 are new compounds. These results indicated that M. spinosus could catalyze the specific C-12 dehydrogenation of 20(S)-protopanaxadiol, as well hydroxylation at different positions. These biocatalytic reactions may be difficult for chemical synthesis. The biotransformed products showed weak in vitro cytotoxic activities. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 20040001136
项目资助者: Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000271177600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50071
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Div Pharmacognost Biotechnol, Beijing 100191, Peoples R China
2.Beijing Inst Drug Control, Beijing 100035, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Li, Huifeng,Ye, Min,Guo, Hongzhu,et al. Biotransformation of 20(S)-protopanaxadiol by Mucor spinosus[J]. PHYTOCHEMISTRY,2009,70(11-12):1416-1420.
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