IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
PTEN expression and suppression of proliferation are associated with Cdx2 overexpression in gastric cancer cells
Bai, Zhi-Gang1; Ye, Ying-Jiang2; Shen, Dan-Hua3; Lu, You-Yong4; Zhang, Zhong-Tao1; Wang, Shan2
关键词Gastric Cancer Cdx2 Pten Pi3k
刊名INTERNATIONAL JOURNAL OF ONCOLOGY
2013-05-01
DOI10.3892/ijo.2013.1875
42期:5页:1682-1691
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]INTESTINAL METAPLASIA ; NUCLEAR PTEN ; PROGNOSIS ; CARCINOMA ; CARCINOGENESIS ; STOMACH ; PATHWAY ; MICE
英文摘要

The prognosis of gastric cancer (GC) is associated with Cdx2 and nuclear PTEN coexpression. This study aimed to determine the expression patterns of Cdx2 and PTEN in various GC tissues and cell lines to identify their relationship in GC. Immunohistochemistry was undertaken to assess the expression patterns of Cdx2 and PTEN in paraffin-embedded specimens of 228 GC patients who had undergone radical D2 gastrostomy with long-term follow-up. Cell growth and tumorigenicity were analyzed in the BGC823 cells with exogenous Cdx2 and any changes in the associated signaling pathways were interpreted in exogenous cdx2 expression and cdx2 knockdown. Cdx2 was found in the nuclei of GC cells in 43.4% (99/228) of the paraffin-embedded biopsies. A higher expression of nuclear PTEN was observed in 36.4% (83/228). Coexpression of Cdx2 and nuclear PTEN was detected in GC tumors (59/228, 25.9%) which correlated with the prognosis of advanced GC patients (p<0.001). The expression levels of Cdx2 and PTEN were variable in the different GC cell lines. However, the trends were similar between PTEN and Cdx2 in GC tissues and cell lines. High expression of Cdx2 and PTEN significantly reduced tumorigenicity in BGC823 cells compared with the empty vector control. Exogenous expression of Cdx2 triggered the upregulation of PTEN expression and decreased PI3K and pAkt expression and vice versa. The coexpression levels of PTEN and Cdx2 in GC tumors correlated with prognosis in GC patients. Cdx2 may play a role in the upregulation of PTEN by triggering PI3K/Akt inactivation in GC cells.

语种英语
WOS记录号WOS:000318053400021
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50081
专题北京大学第二临床医学院_胃肠外科
北京大学第二临床医学院_病理科
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Surg Oncol Lab, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
4.Peking Univ, Mol Oncol Lab, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp Inst, Beijing 100142, Peoples R China
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Bai, Zhi-Gang,Ye, Ying-Jiang,Shen, Dan-Hua,et al. PTEN expression and suppression of proliferation are associated with Cdx2 overexpression in gastric cancer cells[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2013,42(5):1682-1691.
APA Bai, Zhi-Gang,Ye, Ying-Jiang,Shen, Dan-Hua,Lu, You-Yong,Zhang, Zhong-Tao,&Wang, Shan.(2013).PTEN expression and suppression of proliferation are associated with Cdx2 overexpression in gastric cancer cells.INTERNATIONAL JOURNAL OF ONCOLOGY,42(5),1682-1691.
MLA Bai, Zhi-Gang,et al."PTEN expression and suppression of proliferation are associated with Cdx2 overexpression in gastric cancer cells".INTERNATIONAL JOURNAL OF ONCOLOGY 42.5(2013):1682-1691.
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