IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Mild cognitive impairment: Apparent diffusion coefficient in regional gray matter and white matter structures
Ray, Kimberly M.1; Wang, Huali1; Chu, Yong1; Chen, Ya-Fang1; bert, Alo Bert1; Hasso, Anton N.1; Su, Min-Ying1
刊名RADIOLOGY
2006-10-01
DOI10.1148/radiol.2411051051
241期:1页:197-205
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]ALZHEIMERS-DISEASE ; DIAGNOSTIC UTILITY ; CORPUS-CALLOSUM ; TENSOR ; HIPPOCAMPUS ; DEMENTIA ; ATROPHY ; BRAIN ; ATLAS ; MRI
英文摘要

Purpose: To prospectively evaluate regional alterations in the apparent diffusion coefficient (ADC) of cortical gray and white matter and subcortical structures that are known to be involved in mild cognitive impairment (MCI).

Materials and Methods: Magnetic resonance (MR) imaging was performed in 13 patients with MCI (nine men, four women; mean age, 74 years +/- 6 [standard deviation]) and 13 healthy elderly control subjects (seven men, six women; mean age, 75 years +/- 4). This study was approved by the institutional review board and was HIPAA compliant. Each subject gave informed consent. ADC was measured from manually drawn regions of interest (ROIs) of the hippocampus, parahippocampal gyrus, amygdala, corpus callosum, and anterior and posterior cingulate gyrus and from automatically defined frontal, parietal, occipital, and temporal lobes by using template masking. ROIs were outlined on anatomic images then mapped onto ADC maps by using coregistration transformation matrix. A skeleton-based region competition segmentation algorithm was used for segmentation of gray and white matter. The group difference in ADC values was assessed with independent-sample t tests. Pearson correlation analysis was used to examine the correlation of ADC values with age and memory test scores.

Results: Higher ADCs were found in hippocampus, temporal lobe gray matter, and corpus callosum of patients with MCI compared with that of control subjects (P <.05). By pooling all subjects together, an elevated hippocampal ADC was significantly correlated with worse memory performance scores in 5-minute and 30-minute delayed word-list recall tasks (P <.05).

Conclusion: ADCs from gray and white matter of different brain regions can be analyzed by applying an automated template-masking method in conjunction with a skeleton-based region competition segmentation algorithm.

语种英语
WOS记录号WOS:000240765100024
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50082
Collection北京大学精神卫生研究所
作者单位1.Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USA
2.Univ Calif Irvine, Tu & Yuen Ctr Funct Onco Imaging, Irvine, CA 92697 USA
3.Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA
4.Peking Univ, Dept Geriatr Psychiat, Inst Mental Hlth, Beijing 100871, Peoples R China
5.Natl Taiwan Univ Hosp, Dept Med Imaging, Taipei, Taiwan
6.Mauriziano Hosp, Unit Radiol, Inst Canc Res & Treatment, Turin, Italy
7.ISI Fdn, Turin, Italy
Recommended Citation
GB/T 7714
Ray, Kimberly M.,Wang, Huali,Chu, Yong,et al. Mild cognitive impairment: Apparent diffusion coefficient in regional gray matter and white matter structures[J]. RADIOLOGY,2006,241(1):197-205.
APA Ray, Kimberly M..,Wang, Huali.,Chu, Yong.,Chen, Ya-Fang.,bert, Alo Bert.,...&Su, Min-Ying.(2006).Mild cognitive impairment: Apparent diffusion coefficient in regional gray matter and white matter structures.RADIOLOGY,241(1),197-205.
MLA Ray, Kimberly M.,et al."Mild cognitive impairment: Apparent diffusion coefficient in regional gray matter and white matter structures".RADIOLOGY 241.1(2006):197-205.
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