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Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis
Ma, Le1; Dou, Hong-Liang2; Wu, Yi-Qun3; Huang, Yang-Mu1; Huang, Yu-Bei3; Xu, Xian-Rong1; Zou, Zhi-Yong1; Lin, Xiao-Ming1
关键词Lutein Zeaxanthin Age-related Macular Degeneration Meta-analysis
刊名BRITISH JOURNAL OF NUTRITION
2012-02-01
DOI10.1017/S0007114511004260
107期:3页:350-359
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
资助者National Natural Science Foundation of China ; Ministry of Education of China ; National Natural Science Foundation of China ; Ministry of Education of China
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]PIGMENT DENSITY ; HUMAN RETINA ; EYE DISEASE ; VITAMIN-C ; US TWIN ; CAROTENOIDS ; MACULOPATHY ; LIGHT ; ASSOCIATIONS ; SMOKING
英文摘要

Lutein and zeaxanthin are thought to decrease the incidence of age-related macular degeneration (AMD); however, findings have been inconsistent. We conducted a systematic literature review and meta-analysis to evaluate the relationship between dietary intake of lutein and zeaxanthin and AMD risk. Relevant studies were identified by searching five databases up to April 2010. Reference lists of articles were retrieved, and experts were contacted. Literature search, data extraction and study quality assessment were performed independently by two reviewers and results were pooled quantitatively using meta-analysis methods. The potential sources of heterogeneity and publication bias were also estimated. The search yielded six longitudinal cohort studies. The pooled relative risk (RR) for early AMD, comparing the highest with the lowest category of lutein and zeaxanthin intake, was 0.96 (95% CI 0.78, 1.17). Dietary intake of these carotenoids was significantly related with a reduction in risk of late AMD (RR 0.74; 95% CI 0.57, 0.97); and a statistically significant inverse association was observed between lutein and zeaxanthin intake and neovascular AMD risk (RR 0.68; 95% CI 0.51, 0.92). The results were essentially consistent among subgroups stratified by participant characteristics. The findings of the present meta-analysis indicate that dietary lutein and zeaxanthin is not significantly associated with a reduced risk of early AMD, whereas an increase in the intake of these carotenoids may be protective against late AMD. However, additional studies are needed to confirm these relationships.

语种英语
所属项目编号NSFC-30872113
资助者National Natural Science Foundation of China ; Ministry of Education of China ; National Natural Science Foundation of China ; Ministry of Education of China
WOS记录号WOS:000299879300004
引用统计
被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50091
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Eye, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
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GB/T 7714
Ma, Le,Dou, Hong-Liang,Wu, Yi-Qun,et al. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis[J]. BRITISH JOURNAL OF NUTRITION,2012,107(3):350-359.
APA Ma, Le.,Dou, Hong-Liang.,Wu, Yi-Qun.,Huang, Yang-Mu.,Huang, Yu-Bei.,...&Lin, Xiao-Ming.(2012).Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis.BRITISH JOURNAL OF NUTRITION,107(3),350-359.
MLA Ma, Le,et al."Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis".BRITISH JOURNAL OF NUTRITION 107.3(2012):350-359.
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