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学科主题: 临床医学
题名:
Association of serum cotinine levels and the parameters of vascular structure and function in never-smoking adults
作者: Wang, Jin-Wen1; Hu, Da-Yi2
关键词: Arterial stiffness ; risk factor ; secondhand smoke
刊名: JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
发表日期: 2015-12-01
DOI: 10.1016/j.jash.2015.09.003
卷: 9, 期:12, 页:918-924
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ENVIRONMENTAL TOBACCO-SMOKE ; INTIMA-MEDIA THICKNESS ; PULSE-WAVE VELOCITY ; PASSIVE-SMOKING ; BLOOD-PRESSURE ; ENDOTHELIAL FUNCTION ; SECONDHAND SMOKE ; ATHEROSCLEROSIS RISK ; CARDIOVASCULAR RISK ; ARTERIAL STIFFNESS
英文摘要:

Passive smoking is now recognized to be associated with early arterial damage. The aim of this study was to assess the relationship between secondhand smoke (SHS) exposure, measured objectively by serum cotinine level, and the parameters used to assess vascular structure and function among never smokers in North China. From January 2008 to August 2008, 652 adults aged 20-70 years were enrolled. Brachial ankle pulse wave velocity (baPWV), ankle brachial index, and carotid intima-media thickness measurements were performed in all patients. All participants were required to respond to an interviewer-led questionnaire including medical histories and demographic data and to receive blood tests on biochemical indicators. We found that in nonsmokers, higher levels of serum cotinine were positively associated with higher baPWV and brachial pulse pressure after adjusting for heart rate, body mass index, and other confounders. Tests for linear trends for this association were statistically significant. In contrast, no association was present with ankle brachial index and carotid intima-media thickness. In never smokers, higher SHS exposure measured objectively by serum cotinine levels was found to be associated with brachial pulse pressure and baPWV after adjusting for confounders. (c) 2015 American Society of Hypertension. All rights reserved.

语种: 英语
WOS记录号: WOS:000367214500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50094
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Anzhen Hosp, Dept Community Hlth & Prevent, Beijing 100029, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Jin-Wen,Hu, Da-Yi. Association of serum cotinine levels and the parameters of vascular structure and function in never-smoking adults[J]. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION,2015,9(12):918-924.
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