IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Different multiple regeneration capacities of motor and sensory axons in peripheral nerve
Peng Jianping; Yin Xiaofeng; Wang Yanhua; Wang Zhenwei; Kou Yuhui; Xu Chungui; Zhang Peixun; Jiang Baoguo
关键词Peripheral Nerve Multiple Regeneration Motor Sensory
刊名ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
2012-10-01
DOI10.3109/10731199.2012.657205
40期:5页:309-316
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
资助者Chinese National Natural Science Fund for Outstanding Youth ; Chinese 973 Project Planning ; Chinese National Natural Science Youth Fund ; Beijing City Science &amp ; Technology New Star Classification ; Chinese National Natural Science Fund ; Chinese Educational Ministry New Century Excellent Talents Support Project ; Chinese National Natural Science Fund for Outstanding Youth ; Chinese 973 Project Planning ; Chinese National Natural Science Youth Fund ; Beijing City Science &amp ; Technology New Star Classification ; Chinese National Natural Science Fund ; Chinese Educational Ministry New Century Excellent Talents Support Project
研究领域[WOS]Biotechnology & Applied Microbiology ; Engineering ; Materials Science
关键词[WOS]RAT CORTICOSPINAL NEURONS ; CELL-DEATH ; OPTIC-NERVE ; IN-VIVO ; FIBER NUMBERS ; FEMORAL NERVE ; FAMILY-MEMBER ; LONG-TERM ; REINNERVATION ; AXOTOMY
英文摘要

After peripheral nerve injury, axons often project sprouts from the node of Ranvier proximal to the damage site. It is well known that one parent axon can sprout and maintain several regenerating axons. If enough endoneurial tubes in the distal stump are present for the regenerating axons to grow along, then the number of mature myelinated nerve fibers in the distal stump will be greater than the number in the proximal stump. "Multiple regeneration" is used to describe this phenomenon in the peripheral nerve. According to previous studies, a prominent nerve containing many axons can be repaired by the multiple regenerating axons sprouting from another nerve that contains fewer axons. Most peripheral nerves contain a mixture of myelinated motor and sensory axons as well as unmyelinated sensory and autonomic axons. In this study, a multiple regeneration animal model was developed by bridging the proximal common peroneal nerve with the distal common peroneal nerve and the tibial nerve. Differences in the multiple regeneration ratio of motor and sensory nerves were evaluated using histomorphometry one month after ablating the dorsal root ganglion ( DRGs) and ventral roots, respectively. The results suggest that the motor nerves have a significantly larger multiple regeneration ratio than the sensory nerves at two different time points.

语种英语
所属项目编号30625036 ; 2005CB522604 ; 30801169 ; A-2008-10 ; 31171150 ; 81171146 ; 30971526 ; 31040043
资助者Chinese National Natural Science Fund for Outstanding Youth ; Chinese 973 Project Planning ; Chinese National Natural Science Youth Fund ; Beijing City Science &amp ; Technology New Star Classification ; Chinese National Natural Science Fund ; Chinese Educational Ministry New Century Excellent Talents Support Project ; Chinese National Natural Science Fund for Outstanding Youth ; Chinese 973 Project Planning ; Chinese National Natural Science Youth Fund ; Beijing City Science &amp ; Technology New Star Classification ; Chinese National Natural Science Fund ; Chinese Educational Ministry New Century Excellent Talents Support Project
WOS记录号WOS:000309471000002
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50098
专题北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Peng Jianping,Yin Xiaofeng,Wang Yanhua,et al. Different multiple regeneration capacities of motor and sensory axons in peripheral nerve[J]. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,2012,40(5):309-316.
APA Peng Jianping.,Yin Xiaofeng.,Wang Yanhua.,Wang Zhenwei.,Kou Yuhui.,...&Jiang Baoguo.(2012).Different multiple regeneration capacities of motor and sensory axons in peripheral nerve.ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,40(5),309-316.
MLA Peng Jianping,et al."Different multiple regeneration capacities of motor and sensory axons in peripheral nerve".ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY 40.5(2012):309-316.
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