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学科主题: 临床医学
题名:
Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study
作者: Sun, Ningling1; Wang, Hongyi1; Sun, Yuemin2; Chen, Xiaoping3; Wang, Hao4; Zhao, Lianyou5; Wang, Jinping6; Zhu, Zhiming7
关键词: diabetes mellitus ; fasting plasma glucose ; hypertension ; impaired glucose regulation ; oral glucose tolerance test
刊名: HYPERTENSION RESEARCH
发表日期: 2014
DOI: 10.1038/hr.2013.126
卷: 37, 期:1, 页:82-87
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: DISEASE
英文摘要:

To analyze the clinical significance of the oral glucose tolerance test (OGTT) in the assessment of abnormal glucose metabolism in Chinese patients with hypertension. In this cross-sectional study of 10 173 hypertensive adult patients from eight sites in China, data on patient, clinical and disease characteristics were collected, and fasting plasma glucose (FPG) levels were measured. A subset of 5322 patients also underwent an OGTT. Abnormal glucose metabolism (impaired glucose regulation (IGR) or diabetes mellitus (DM)) was detected in 31.1% of the 10 173 patients by FPG testing and in 67% of the 5322 patients by OGTT. OGTT increased the detection rate by 35.8%. Patients with FPG levels >= 5.6 and >= 6.1 mmol l(-1) had the mean OGTT 2-h plasma glucose levels of 8.79 and 9.68 mmol l(-1), respectively. Compared with normoglycemic patients, those with IGR or DM had higher rates of total proteinuria (normoglycemic 15.8% vs. IGR 22.1% vs. DM 33.7%, P<0.001), a lower absolute estimated glomerular filtration rate (eGFR; in ml min(-1) per 1.73 m(2)) (82.9 vs. 80.77 vs. 79.74, P-0.06) and a higher prevalence of cardiovascular disease (normoglycemic 17.6% vs. IGR/DM 13.8%, P<0.001). Abnormal abdominal circumference, eGFR <= 60 ml min(-1) per 1.73 m(2), and proteinuria were independently associated with abnormal glucose metabolism (IGR or DM). Hypertensive patients who are diabetic or at risk of diabetes are at greater risk of renal damage and cardiovascular disease than those who are normoglycemic. It is insufficient to assess the glucose metabolism status of Chinese hypertensive patients using only FPG testing; the use of OGTT can increase the detection rate by 35.8%. Patients whose FPG levels were <5.6 mmol l(-1) may be found to have abnormal glucose metabolism after an OGTT.

语种: 英语
项目资助者: Bayer Healthcare (China)
WOS记录号: WOS:000329317600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50102
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100044, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Dept Cardiol, Tianjin, Peoples R China
3.Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu 610064, Peoples R China
4.Henan Prov Peoples Hosp, Dept Hypertens, Zhengzhou, Peoples R China
5.Fourth Mil Med Univ, Tangdu Hosp, Dept Cardiol, Chongqing, Peoples R China
6.Daqing Oilfield Gen Hosp Heilongjiang Prov, Dept Cardiol, Daqing, Peoples R China
7.Daping Hosp Chongqing, Dept Hypertens & Endocrinol, Chongqing, Peoples R China

Recommended Citation:
Sun, Ningling,Wang, Hongyi,Sun, Yuemin,et al. Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study[J]. HYPERTENSION RESEARCH,2014,37(1):82-87.
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