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Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study
Sun, Ningling1; Wang, Hongyi1; Sun, Yuemin2; Chen, Xiaoping3; Wang, Hao4; Zhao, Lianyou5; Wang, Jinping6; Zhu, Zhiming7
关键词Diabetes Mellitus Fasting Plasma Glucose Hypertension Impaired Glucose Regulation Oral Glucose Tolerance Test
刊名HYPERTENSION RESEARCH
2014
DOI10.1038/hr.2013.126
37期:1页:82-87
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]DISEASE
英文摘要

To analyze the clinical significance of the oral glucose tolerance test (OGTT) in the assessment of abnormal glucose metabolism in Chinese patients with hypertension. In this cross-sectional study of 10 173 hypertensive adult patients from eight sites in China, data on patient, clinical and disease characteristics were collected, and fasting plasma glucose (FPG) levels were measured. A subset of 5322 patients also underwent an OGTT. Abnormal glucose metabolism (impaired glucose regulation (IGR) or diabetes mellitus (DM)) was detected in 31.1% of the 10 173 patients by FPG testing and in 67% of the 5322 patients by OGTT. OGTT increased the detection rate by 35.8%. Patients with FPG levels >= 5.6 and >= 6.1 mmol l(-1) had the mean OGTT 2-h plasma glucose levels of 8.79 and 9.68 mmol l(-1), respectively. Compared with normoglycemic patients, those with IGR or DM had higher rates of total proteinuria (normoglycemic 15.8% vs. IGR 22.1% vs. DM 33.7%, P<0.001), a lower absolute estimated glomerular filtration rate (eGFR; in ml min(-1) per 1.73 m(2)) (82.9 vs. 80.77 vs. 79.74, P-0.06) and a higher prevalence of cardiovascular disease (normoglycemic 17.6% vs. IGR/DM 13.8%, P<0.001). Abnormal abdominal circumference, eGFR <= 60 ml min(-1) per 1.73 m(2), and proteinuria were independently associated with abnormal glucose metabolism (IGR or DM). Hypertensive patients who are diabetic or at risk of diabetes are at greater risk of renal damage and cardiovascular disease than those who are normoglycemic. It is insufficient to assess the glucose metabolism status of Chinese hypertensive patients using only FPG testing; the use of OGTT can increase the detection rate by 35.8%. Patients whose FPG levels were <5.6 mmol l(-1) may be found to have abnormal glucose metabolism after an OGTT.

语种英语
WOS记录号WOS:000329317600014
资助机构Bayer Healthcare (China)
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50102
专题北京大学第二临床医学院
北京大学第二临床医学院_心血管内科
作者单位1.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100044, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Dept Cardiol, Tianjin, Peoples R China
3.Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu 610064, Peoples R China
4.Henan Prov Peoples Hosp, Dept Hypertens, Zhengzhou, Peoples R China
5.Fourth Mil Med Univ, Tangdu Hosp, Dept Cardiol, Chongqing, Peoples R China
6.Daqing Oilfield Gen Hosp Heilongjiang Prov, Dept Cardiol, Daqing, Peoples R China
7.Daping Hosp Chongqing, Dept Hypertens & Endocrinol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714
Sun, Ningling,Wang, Hongyi,Sun, Yuemin,et al. Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study[J]. HYPERTENSION RESEARCH,2014,37(1):82-87.
APA Sun, Ningling.,Wang, Hongyi.,Sun, Yuemin.,Chen, Xiaoping.,Wang, Hao.,...&Zhu, Zhiming.(2014).Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study.HYPERTENSION RESEARCH,37(1),82-87.
MLA Sun, Ningling,et al."Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study".HYPERTENSION RESEARCH 37.1(2014):82-87.
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