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学科主题: 药学
题名:
HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract
作者: Zhang, JL1; Yu, HL1; Sheng, YX1; Li, L1; Ye, M1; Guo, D1
关键词: salvianolic acid B ; Radix Salviae Miltiorhizae ; high-performance liquid chromatography ; pharmacokinetic studies
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2005
DOI: 10.1002/bmc.408
卷: 19, 期:1, 页:15-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
英文摘要:

A precise and reproducible HPLC method has been established and validated for determination of salvianolic acid B (SaIB) in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract. Liquid-liquid extraction was adopted for the sample preparation. Separation was accomplished on a C, column with a linear gradient elution consisting of acetonitrile and aqueous phosphoric acid. Ultraviolet detection was at 280 run. The method was validated over the concentration range 10.8-259.4 mug/mL using 1 mL of plasma. The assay was linear over this concentration range with a coefficient of variation less than 7%. The extraction recovery of SaIB was within the range 71-83% with RSD 11%. The mean recovery of the internal standard was 84% (n = 6) with RSD of 5.6%. This method is suitable to determine SalB in plasma and to investigate the pharmacokinelics of SalB. Copyright (C) 2004 John Wiley Sons, Ltd.

语种: 英语
WOS记录号: WOS:000227233400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50107
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, JL,Yu, HL,Sheng, YX,et al. HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract[J]. BIOMEDICAL CHROMATOGRAPHY,2005,19(1):15-18.
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