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HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract
Zhang, JL1; Yu, HL1; Sheng, YX1; Li, L1; Ye, M1; Guo, D1
关键词Salvianolic Acid b Radix Salviae Miltiorhizae High-performance Liquid Chromatography Pharmacokinetic Studies
刊名BIOMEDICAL CHROMATOGRAPHY
2005
DOI10.1002/bmc.408
19期:1页:15-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
英文摘要

A precise and reproducible HPLC method has been established and validated for determination of salvianolic acid B (SaIB) in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract. Liquid-liquid extraction was adopted for the sample preparation. Separation was accomplished on a C, column with a linear gradient elution consisting of acetonitrile and aqueous phosphoric acid. Ultraviolet detection was at 280 run. The method was validated over the concentration range 10.8-259.4 mug/mL using 1 mL of plasma. The assay was linear over this concentration range with a coefficient of variation less than 7%. The extraction recovery of SaIB was within the range 71-83% with RSD 11%. The mean recovery of the internal standard was 84% (n = 6) with RSD of 5.6%. This method is suitable to determine SalB in plasma and to investigate the pharmacokinelics of SalB. Copyright (C) 2004 John Wiley Sons, Ltd.

语种英语
WOS记录号WOS:000227233400003
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50107
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学第一临床医学院_医疗耗材科
作者单位1.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, JL,Yu, HL,Sheng, YX,et al. HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract[J]. BIOMEDICAL CHROMATOGRAPHY,2005,19(1):15-18.
APA Zhang, JL,Yu, HL,Sheng, YX,Li, L,Ye, M,&Guo, D.(2005).HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract.BIOMEDICAL CHROMATOGRAPHY,19(1),15-18.
MLA Zhang, JL,et al."HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract".BIOMEDICAL CHROMATOGRAPHY 19.1(2005):15-18.
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