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学科主题临床医学
Signal Transducer and Activator of Transcription 4 in Liver Diseases
Wang, Yan1; Qu, Aijuan3,4; Wang, Hua2
关键词Stat4 Cytokines Liver Injury Chronic Hepatitis Liver Fibrosis Hepatocellular Carcinoma
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2015
DOI10.7150/ijbs.11164
11期:4页:448-455
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
关键词[WOS]NATURAL-KILLER-CELLS ; IFN-GAMMA PRODUCTION ; HEPATIC ISCHEMIA/REPERFUSION INJURY ; STAT4 SERINE PHOSPHORYLATION ; A-INDUCED HEPATITIS ; IL-12 GENE-THERAPY ; T-CELLS ; HEPATOCELLULAR-CARCINOMA ; INTERFERON-GAMMA ; DEPENDENT MECHANISM
英文摘要

STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm. STAT4 regulates various genes expression as a transcription factor after it is phosphorylated, dimerizes and translocates to the nucleus. STAT4 activation is detected virtually in the liver of several mouse models of liver injury, as well as the human liver of chronic liver diseases. STAT4 gene polymorphism has been shown to be associated with the antiviral response in chronic hepatitis C and drug-induced liver injury (DILI), primary biliary cirrhosis (PBC), HCV-associated liver fibrosis and in hepatocellular carcinoma (HCC). However, the roles of STAT4 in the pathogeneses of liver diseases are still not understood entirely. This review summarizes the recent advances on the functional roles of STAT4 and its related cytokines in liver diseases, especially in regulating hepatic anti-viral responses, inflammation, proliferation, apoptosis and tumorigenesis. Targeting STAT4 signaling pathway might be a promising strategy in developing therapeutic approaches for treating hepatitis in order to prevent further injury like cirrhosis and liver cancer.

语种英语
WOS记录号WOS:000350408500009
项目编号81300312 ; 81372577 ; CFHPC20132028
资助机构National Natural Science Foundation of China ; TianQing liver diseases research fund of the China Hepatitis Prevention and Treatment of Foundation
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50108
专题北京大学第一临床医学院_感染疾病科
作者单位1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei 230032, Peoples R China
3.Capital Med Univ, Sch Basic Med Sci, Inst Hypox Dis, Beijing 100069, Peoples R China
4.Capital Med Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100069, Peoples R China
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GB/T 7714
Wang, Yan,Qu, Aijuan,Wang, Hua. Signal Transducer and Activator of Transcription 4 in Liver Diseases[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2015,11(4):448-455.
APA Wang, Yan,Qu, Aijuan,&Wang, Hua.(2015).Signal Transducer and Activator of Transcription 4 in Liver Diseases.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,11(4),448-455.
MLA Wang, Yan,et al."Signal Transducer and Activator of Transcription 4 in Liver Diseases".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 11.4(2015):448-455.
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