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PAK: an essential motif for forming beta-turn structures and exhibiting the thrombolytic effect of P6A and its analogs
Zhao, Ming2; Jia, Xin3; Wang, Chao3; Li, Qin3; Zhou, Kexiang2; Wang, Lili1; Liu, Hu1; Peng, Shiqi2
关键词Thrombolysis Fibrinolysis Peptide 6a Nmr Structure Beta-turn Plasminogen
刊名BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
2007-12-01
DOI10.1139/O07-143
85期:6页:730-740
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]DEGRADATION PRODUCT PEPTIDE-6A ; ANGIOTENSIN CONVERTING ENZYME ; PLASMINOGEN-ACTIVATOR ; VASOACTIVE PEPTIDES ; GLOBULAR-PROTEINS ; CRYSTAL-STRUCTURE ; BLOOD-FLOW ; FIBRINOGEN FRAGMENT ; HYDROPHOBIC BASIS ; ESCHERICHIA-COLI
英文摘要

Ala-Arg-Pro-Ala-Lys (ARPAK; also known as P6A) and 19 of its analogs were synthesized, and their thrombolytic activities were assessed in vitro and in vivo. The solution structures of 12 of the P6A analogs were determined using nuclear magnetic resonance (NMR) spectroscopy. The thrombolytic activity and conformational structure relationship was analyzed. We found that the Pro-Ala-Lys (PAK) sequence was essential for thrombolytic activity and was also responsible for the beta-turn structure found in the P6A analogs studied. The well defined beta turn may act as a binding head with the protruding lysine side-chain (positively charged) found at the target site for target recognition. Additionally, the N-terminal residue may be critical for thrombolytic activity, which for PAK-containing peptides, is likely achieved via a plasminogen-dependent pathway.

语种英语
WOS记录号WOS:000252316300008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50118
专题北京大学药学院
北京大学第一临床医学院_药剂科
作者单位1.Mem Univ Newfoundland, Sch Pharm, St John, NF A1B 3V6, Canada
2.Capital Med Univ, Coll Chem Biol & Pharmaceut Sci, Beijing 100069, Peoples R China
3.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Zhao, Ming,Jia, Xin,Wang, Chao,et al. PAK: an essential motif for forming beta-turn structures and exhibiting the thrombolytic effect of P6A and its analogs[J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,2007,85(6):730-740.
APA Zhao, Ming.,Jia, Xin.,Wang, Chao.,Li, Qin.,Zhou, Kexiang.,...&Peng, Shiqi.(2007).PAK: an essential motif for forming beta-turn structures and exhibiting the thrombolytic effect of P6A and its analogs.BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,85(6),730-740.
MLA Zhao, Ming,et al."PAK: an essential motif for forming beta-turn structures and exhibiting the thrombolytic effect of P6A and its analogs".BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 85.6(2007):730-740.
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