IR@PKUHSC  > 北京大学第三临床医学院  > 放射科
学科主题临床医学
Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI
Lang, Ning1; Su, Min-Ying2; Yu, Hon J.2; Yuan, Huishu1
关键词Tuberculosis Metastatic Cancer Spine Dynamic Contrast-enhanced Mri Differential Diagnosis
刊名EUROPEAN SPINE JOURNAL
2015-08-01
DOI10.1007/s00586-015-3851-z
24期:8页:1729-1737
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Orthopedics
研究领域[WOS]Neurosciences & Neurology ; Orthopedics
关键词[WOS]BONE-MARROW ; SOFT-TISSUE ; TUMOR ; BENIGN ; INFILTRATION ; PARAMETERS ; GADOLINIUM ; PERFUSION ; PATTERNS ; MYELOMA
英文摘要

To investigate the differences between imaging features of spinal tuberculosis (TB) and metastatic cancer measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The presentation of TB on convention MRI may not show the typical TB signs, and they may be mis-diagnosed as malignant diseases. DCE-MRI may provide additional information to help making differential diagnosis.

DCE-MRI was performed in 24 TB and 22 metastatic cancer patients. The DCE kinetic pattern was determined as "wash-out", "plateau" or "persistent enhancement". The characteristic DCE parameters were calculated from the signal intensity time course. The two-compartmental pharmacokinetic model was used to obtain K (trans), which is the parameter associated with the delivery of MR contrast agents into the lesion, and k (ep), which is the parameter associated with the distribution and clearance of contrast agents from the lesion.

Of the 24 TB, one case showed the wash-out kinetic pattern, 12 cases showed the plateau pattern, and 11 cases showed the persistent enhancement pattern. Of the 22 metastatic cancers, 12 cases showed wash-out, 7 cases showed plateau, and 3 cases showed persistent enhancement patterns. Compared to the metastatic cancer group, the TB group had a lower k (ep) (0.27 +/- A 0.15 vs. 0.49 +/- A 0.23 min(-1), P < 0.001). The ROC analysis showed that the area under the curve was 0.780 for k (ep).

DCE-MRI may provide additional information for differentiation between spinal TB and metastasis, when their manifestations on conventional imaging were similar.

语种英语
WOS记录号WOS:000358372700018
项目编号R01 CA 127927 ; 81471634
资助机构National Institute of Health in the United States ; National Natural Science Foundation of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50120
专题北京大学第三临床医学院_放射科
作者单位1.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
2.Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Dept Radiol Sci, Irvine, CA 92697 USA
推荐引用方式
GB/T 7714
Lang, Ning,Su, Min-Ying,Yu, Hon J.,et al. Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI[J]. EUROPEAN SPINE JOURNAL,2015,24(8):1729-1737.
APA Lang, Ning,Su, Min-Ying,Yu, Hon J.,&Yuan, Huishu.(2015).Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI.EUROPEAN SPINE JOURNAL,24(8),1729-1737.
MLA Lang, Ning,et al."Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI".EUROPEAN SPINE JOURNAL 24.8(2015):1729-1737.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lang, Ning]的文章
[Su, Min-Ying]的文章
[Yu, Hon J.]的文章
百度学术
百度学术中相似的文章
[Lang, Ning]的文章
[Su, Min-Ying]的文章
[Yu, Hon J.]的文章
必应学术
必应学术中相似的文章
[Lang, Ning]的文章
[Su, Min-Ying]的文章
[Yu, Hon J.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。