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学科主题: 临床医学
题名:
Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI
作者: Lang, Ning1; Su, Min-Ying2; Yu, Hon J.2; Yuan, Huishu1
关键词: Tuberculosis ; Metastatic cancer ; Spine ; Dynamic contrast-enhanced MRI ; Differential diagnosis
刊名: EUROPEAN SPINE JOURNAL
发表日期: 2015-08-01
DOI: 10.1007/s00586-015-3851-z
卷: 24, 期:8, 页:1729-1737
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Orthopedics
研究领域[WOS]: Neurosciences & Neurology ; Orthopedics
关键词[WOS]: BONE-MARROW ; SOFT-TISSUE ; TUMOR ; BENIGN ; INFILTRATION ; PARAMETERS ; GADOLINIUM ; PERFUSION ; PATTERNS ; MYELOMA
英文摘要:

To investigate the differences between imaging features of spinal tuberculosis (TB) and metastatic cancer measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The presentation of TB on convention MRI may not show the typical TB signs, and they may be mis-diagnosed as malignant diseases. DCE-MRI may provide additional information to help making differential diagnosis.

DCE-MRI was performed in 24 TB and 22 metastatic cancer patients. The DCE kinetic pattern was determined as "wash-out", "plateau" or "persistent enhancement". The characteristic DCE parameters were calculated from the signal intensity time course. The two-compartmental pharmacokinetic model was used to obtain K (trans), which is the parameter associated with the delivery of MR contrast agents into the lesion, and k (ep), which is the parameter associated with the distribution and clearance of contrast agents from the lesion.

Of the 24 TB, one case showed the wash-out kinetic pattern, 12 cases showed the plateau pattern, and 11 cases showed the persistent enhancement pattern. Of the 22 metastatic cancers, 12 cases showed wash-out, 7 cases showed plateau, and 3 cases showed persistent enhancement patterns. Compared to the metastatic cancer group, the TB group had a lower k (ep) (0.27 +/- A 0.15 vs. 0.49 +/- A 0.23 min(-1), P < 0.001). The ROC analysis showed that the area under the curve was 0.780 for k (ep).

DCE-MRI may provide additional information for differentiation between spinal TB and metastasis, when their manifestations on conventional imaging were similar.

语种: 英语
所属项目编号: R01 CA 127927 ; 81471634
项目资助者: National Institute of Health in the United States ; National Natural Science Foundation of China
WOS记录号: WOS:000358372700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50120
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
2.Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Dept Radiol Sci, Irvine, CA 92697 USA

Recommended Citation:
Lang, Ning,Su, Min-Ying,Yu, Hon J.,et al. Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI[J]. EUROPEAN SPINE JOURNAL,2015,24(8):1729-1737.
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