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学科主题: 药学
题名:
Structure-activity relationships of saponins from Gleditsia sinensis in cytotoxicity and induction of apoptosis
作者: Zhong, L; Li, P; Han, J; Qu, GQ; Guo, D
关键词: Gleditsia sinensis ; Leguminosae ; saponin ; cytotoxiciiy ; apoptosis ; structure-activity relationship
刊名: PLANTA MEDICA
发表日期: 2004-09-01
DOI: 10.1055/s-2004-827225
卷: 70, 期:9, 页:797-802
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: TUMOR-CELL PROLIFERATION ; TRITERPENOID SAPONINS ; CYCLE ARREST
英文摘要:

Thirteen compounds were isolated from the anomalous fruits of Gleditsia sinensis on the basis of bioassay-guided fractionation. These saponins together with six analogues or related compounds were tested for their cytotoxicities against six tumor cell lines by the MTT method. The induction of apoptosis in HL-60 cells by these compounds was determined through flow cytometric analysis. Some structure-activity relationships in cytotoxicity and induction of apoptosis were identified. The evaluation of the cytotoxicity and the ability to induce apoptosis revealed that some important structural features are required for activity. A valuable model which enables prediction of their activities was established and may be employed for the drug design of new Gleditsia saponin analogues.

语种: 英语
WOS记录号: WOS:000224440700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50121
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Zhong, L,Li, P,Han, J,et al. Structure-activity relationships of saponins from Gleditsia sinensis in cytotoxicity and induction of apoptosis[J]. PLANTA MEDICA,2004,70(9):797-802.
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