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学科主题: 精神卫生
题名:
GM1 ganglioside regulates the proteolysis of amyloid precursor protein
作者: Zha, Q1; Ruan, Y1; Hartmann, T1; Beyreuther, K1; Zhang, D1
关键词: amyloid beta-protein ; Alzheimer&prime ; s disease ; GM1 ganglioside ; amyloid beta-protein precursor ; proteolysis
刊名: MOLECULAR PSYCHIATRY
发表日期: 2004-10-01
DOI: 10.1038/sj.mp.4001509
卷: 9, 期:10, 页:946-952
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]: BIOTIN-LABELED GANGLIOSIDE ; KINASE-C-ALPHA ; ALZHEIMERS-DISEASE ; EXOGENOUS GANGLIOSIDES ; LIPID RAFTS ; A-BETA ; CEREBROSPINAL-FLUID ; TRANSFECTED CELLS ; PLASMA-MEMBRANE ; CULTURED-CELLS
英文摘要:

Plaques containing amyloid beta-peptides (Abeta) are a major feature in Alzheimer′s disease ( AD), and GM1 ganglioside is an important component of cellular plasma membranes and especially enriched in lipid raft. GM1-bound Abeta (GM1/Abeta), found in brains exhibiting early pathological changes of AD including diffuse plaques, has been suggested to be involved in the initiation of amyloid fibril formation in vivo by acting as a seed. However, the role of GM1 in amyloid beta-protein precursor (APP) processing is not yet defined. In this study, we report that exogenous GM1 ganglioside promotes Abeta biogenesis and decreases sAPPalpha secretion in SH-SY5Y and COS7 cells stably transfected with human APP695 cDNA without affecting full-length APP and the sAPPbeta levels. We also observe that GM1 increases extracellular levels of Abeta in primary cultures of mixed rat cortical neurons transiently transfected with human APP695 cDNA. These findings suggest a regulatory role for GM1 in APP processing pathways.

语种: 英语
WOS记录号: WOS:000224092100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50123
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Dept Biochem, Beijing 100871, Peoples R China
2.Univ Heidelberg, Ctr Mol Biol, ZMBH, Heidelberg, Germany

Recommended Citation:
Zha, Q,Ruan, Y,Hartmann, T,et al. GM1 ganglioside regulates the proteolysis of amyloid precursor protein[J]. MOLECULAR PSYCHIATRY,2004,9(10):946-952.
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