IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
GM1 ganglioside regulates the proteolysis of amyloid precursor protein
Zha, Q()1; Ruan, Y()1; Hartmann, T()1; Beyreuther, K()1; Zhang, D()1
关键词Amyloid Beta-protein Alzheimer&Prime s Disease Gm1 Ganglioside Amyloid Beta-protein Precursor Proteolysis
刊名MOLECULAR PSYCHIATRY
2004-10-01
DOI10.1038/sj.mp.4001509
9期:10页:946-952
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]BIOTIN-LABELED GANGLIOSIDE ; KINASE-C-ALPHA ; ALZHEIMERS-DISEASE ; EXOGENOUS GANGLIOSIDES ; LIPID RAFTS ; A-BETA ; CEREBROSPINAL-FLUID ; TRANSFECTED CELLS ; PLASMA-MEMBRANE ; CULTURED-CELLS
英文摘要

Plaques containing amyloid beta-peptides (Abeta) are a major feature in Alzheimer′s disease ( AD), and GM1 ganglioside is an important component of cellular plasma membranes and especially enriched in lipid raft. GM1-bound Abeta (GM1/Abeta), found in brains exhibiting early pathological changes of AD including diffuse plaques, has been suggested to be involved in the initiation of amyloid fibril formation in vivo by acting as a seed. However, the role of GM1 in amyloid beta-protein precursor (APP) processing is not yet defined. In this study, we report that exogenous GM1 ganglioside promotes Abeta biogenesis and decreases sAPPalpha secretion in SH-SY5Y and COS7 cells stably transfected with human APP695 cDNA without affecting full-length APP and the sAPPbeta levels. We also observe that GM1 increases extracellular levels of Abeta in primary cultures of mixed rat cortical neurons transiently transfected with human APP695 cDNA. These findings suggest a regulatory role for GM1 in APP processing pathways.

语种英语
WOS记录号WOS:000224092100008
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50123
专题北京大学精神卫生研究所
北京大学第一临床医学院_妇产科
作者单位1.Peking Univ, Inst Mental Hlth, Dept Biochem, Beijing 100871, Peoples R China
2.Univ Heidelberg, Ctr Mol Biol, ZMBH, Heidelberg, Germany
推荐引用方式
GB/T 7714
Zha, Q,Ruan, Y,Hartmann, T,et al. GM1 ganglioside regulates the proteolysis of amyloid precursor protein[J]. MOLECULAR PSYCHIATRY,2004,9(10):946-952.
APA Zha, Q,Ruan, Y,Hartmann, T,Beyreuther, K,&Zhang, D.(2004).GM1 ganglioside regulates the proteolysis of amyloid precursor protein.MOLECULAR PSYCHIATRY,9(10),946-952.
MLA Zha, Q,et al."GM1 ganglioside regulates the proteolysis of amyloid precursor protein".MOLECULAR PSYCHIATRY 9.10(2004):946-952.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zha, Q()]的文章
[Ruan, Y()]的文章
[Hartmann, T()]的文章
百度学术
百度学术中相似的文章
[Zha, Q()]的文章
[Ruan, Y()]的文章
[Hartmann, T()]的文章
必应学术
必应学术中相似的文章
[Zha, Q()]的文章
[Ruan, Y()]的文章
[Hartmann, T()]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。