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学科主题: 临床医学
题名:
Prevalence of type-specific human papillomavirus and pap results in Chinese women: a multi-center, population-based cross-sectional study
作者: Velicer, Christine10; Wu, En-Qi1,2; Liu, Bin1,2; Cui, Jian-Feng1,2; Chen, Wen1,2; Wang, Jian-Bing1,2; Lu, Liang1,2; Niyazi, Mayineur3; Zhao, Chao4; Ren, Sheng-Da5; Li, Chang-Qing6; Gong, Xiang-Zhen7; Smith, Jennifer S.8; Belinson, Jerome L.9; Liaw, Kai-Li10; Qiao, You-Lin1,2
关键词: Human papillomavirus ; Cervical cancer ; Type-specific prevalence ; China ; Population-based study
刊名: CANCER CAUSES & CONTROL
发表日期: 2013-04-01
DOI: 10.1007/s10552-013-0162-8
卷: 24, 期:4, 页:795-803
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: REPUBLIC-OF-CHINA ; INVASIVE CERVICAL-CANCER ; INFECTION ; METAANALYSIS ; PROVINCE ; HPV ; CLASSIFICATION ; WORLDWIDE ; NEOPLASIA ; PRIMERS
英文摘要:

To estimate the burden of human papillomavirus (HPV) infection among sexually active women in China.

We conducted a multi-center, population-based study between May 2006 and April 2007. A total of 4,215 women aged 17-54 years were surveyed from five geographical sites: Beijing, Shanghai, Shanxi, Henan, and Xinjiang. Direct endocervical exfoliated cells were collected from consenting participants for Sure Path liquid-based cytology (BD) and HPV testing. HPV testing was performed with Hybrid Capture II (Qiagen) with high-risk and low-risk probes, and Linear Array (Roche) was utilized for HPV genotyping.

Approximately 11 % of the study population had a cytological abnormality (ASCUS or worse). HPV prevalence in the entire study population was 14.3 % (age-standardized to the world standard female population 14.5 %). The most prevalent types found were HPV16 (2.9 %), HPV52 (1.7 %), HPV58 (1.5 %), HPV33 (1 %), and HPV18 (0.8 %). Patterns of HPV prevalence differed by age, geographic region, and cytology findings. However, HPV16 was predominant among all grades of cytological abnormalities for all areas.

Although HPV18 appeared to be less frequent among population-based samples of China, given the high prevalence of HPV 16 and 18 in high-grade squamous intraepithelial lesion (HSIL) or worse pap abnormalities, prophylactic HPV16/18 vaccines should substantially reduce the burden of cervical cancer in China.

语种: 英语
项目资助者: Merck Sharp and Dohme
WOS记录号: WOS:000316352900018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50124
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA
2.Chinese Acad Med Sci, Dept Canc Epidemiol, Canc Inst & Hosp, Beijing 100730, Peoples R China
3.Peking Union Med Coll, Beijing 100021, Peoples R China
4.Xinjiang Med Univ, Dept Gynecol, Peoples Hosp Xinjiang Uygur Autonomous Reg, Urumqi, Peoples R China
5.Peking Univ, Dept Obstet & Gynecol, Peoples Hosp, Beijing 100871, Peoples R China
6.Xiangyuan Women & Children Hosp, Beijing, Shanxi, Peoples R China
7.Xinmi Women & Children Hosp, Beijing, Henan, Peoples R China
8.Dis Control & Prevent Ctr Hongkou Dist, Shanghai, Peoples R China
9.Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA
10.Merck Sharp & Dohme Ltd, Whitehouse Stn, NJ USA

Recommended Citation:
Velicer, Christine,Wu, En-Qi,Liu, Bin,et al. Prevalence of type-specific human papillomavirus and pap results in Chinese women: a multi-center, population-based cross-sectional study[J]. CANCER CAUSES & CONTROL,2013,24(4):795-803.
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