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学科主题: 临床医学
题名:
Long-Term Efficacy of Olmesartan Medoxomil in Chinese Hypertensive Patients as Assessed by Clinic, Ambulatory and Home Blood Pressure Measurements
作者: Wang, Ji-Guang1; Sun, Ning-Ling2; Ke, Yuan-Nan3; Zhang, Bo-Heng4; Ikegami, Naotaka5; Zhu, Jun-Ren6
刊名: CLINICAL DRUG INVESTIGATION
发表日期: 2012
DOI: 10.1007/s40261-012-0003-7
卷: 32, 期:11, 页:729-734
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: MODERATE ESSENTIAL-HYPERTENSION ; ANTIHYPERTENSIVE EFFICACY ; SAFETY ; AMLODIPINE ; SOCIETY
英文摘要:

Background and Objectives There is limited information on the long-term efficacy and safety of olmesartan medoxomil in the management of hypertension in Chinese patients. We therefore conducted the present multicentre, single-arm, prospective, observational study to investigate the 24-week efficacy and safety of olmesartan medoxomil in patients with mild to moderate hypertension.

Methods Eligible patients (diastolic blood pressure [BP] 90-109 mmHg and systolic BP <180 mmHg off antihypertensive medication) were started on olmesartan medoxomil 20 mg once daily, with the possible up-titration to 40 mg once daily during 24 weeks of follow-up, to control clinic BP to the target level (<140/90 and <130/80 mmHg in diabetes mellitus). In a subset of enrolled patients, 24-h ambulatory and home BP monitoring were also performed.

Results In the intent-to-treat analysis (n = 348), at 24 weeks of follow-up, the mean +/- SD changes from baseline in clinic systolic/diastolic BP were 21.2 +/- 14.2/16.0 +/- 8.8 mmHg (p < 0.001). The proportions of patients who achieved the goal BP for systolic, diastolic and both were 81, 80 and 75 %, respectively. Olmesartan medoxomil also significantly (p < 0.001) reduced systolic/diastolic BP measured at patients′ homes by 17.7 +/- 13.1/12.1 +/- 7.9 mmHg from baseline (n = 109), and reduced mean 24-h, daytime and night-time ambulatory BP by 13.3 +/- 16.3/7.6 +/- 9.5 mmHg, 13.9 +/- 17.4/8.0 +/- 10.4 mmHg and 12.3 +/- 18.1/6.8 +/- 10.2 mmHg, respectively (n = 87). Seven (2.0 %) serious adverse events were reported during follow-up.

Conclusion In Chinese hypertensive patients, olmesartan medoxomil is efficacious in lowering BP as assessed by three different BP-measuring methods and has an acceptable long-term safety and tolerability profile.

语种: 英语
项目资助者: Daiichi-Sankyo Pharmaceutical (Shanghai) Co. Ltd.
WOS记录号: WOS:000311181400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50127
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hypertens, Ctr Epidemiol Studies & Clin Trials,Ruijin Hosp, Shanghai 200025, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
3.China Japan Friendship Hosp, Dept Cardiol, Beijing, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Div Sci Res, Shanghai 200433, Peoples R China
5.Daiichi Sankyo Pharmaceut Shanghai Co Ltd, R&D Div, Shanghai, Peoples R China
6.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China

Recommended Citation:
Wang, Ji-Guang,Sun, Ning-Ling,Ke, Yuan-Nan,et al. Long-Term Efficacy of Olmesartan Medoxomil in Chinese Hypertensive Patients as Assessed by Clinic, Ambulatory and Home Blood Pressure Measurements[J]. CLINICAL DRUG INVESTIGATION,2012,32(11):729-734.
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