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IR@PKUHSC  > 北京大学第三临床医学院  > 内分泌科  > 期刊论文
学科主题: 临床医学
题名:
Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus
作者: Wang, GY1; Li, QF1; Niu, TH1; Chen, CZ1; Xu, XP1
关键词: muscle glycogen synthase gene ; beta(3)-adrenergic receptor gene ; type 2 diabetes mellitus ; postprandial glucose ; serum uric acid
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2002-09-01
卷: 115, 期:9, 页:1308-1311
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GLYCOGEN-SYNTHASE GENE ; INSULIN-RESISTANCE ; POLYMORPHISM
英文摘要:

Objective To determine the relationships of Met416Val and Xbal polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the beta(3)-adrenergic-receptor (beta(3)-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population.

Methods Polymerase chain reaction-oligonucleotide ligation assay and restriction fragment length polymorphism assay were used to evaluate the GYS1 and beta(3)-AR gene polymorphisms in 102 pairs of case-control Chinese spouses.

Results Subjects with Met416Val variant had a significantly higher 2-hour post-glucose level than subjects without this variant had in diabetic group (P = 0.032). The Met416Val polymorphism of GYS1 gene was not significantly associated with the risk of type 2 DM (adjusted OR = 1.67; 95% Cl: 0.73 - 3.81, P = 0.223). Subjects with Trp64Arg variant had a significantly higher serum uric acid level than subjects without this variant had in diabetic group (P = 0. 034). The combination of BMI and Arg64 allele carrier of the beta(3)-AR gene increased the diabetic risk over four-fold (adjusted OR = 4.00; 95% Cl: 1.53 - 10.45, P = 0.005).

Conclusions In the Chinese population, Met416Val polymorphism is identified in a subgroup of diabetic subjects with high 2-hour post-glucose. It will explain why some diabetic patients appear to be genetically predisposed to developing high postpradial glucose level. The presence of the Arg64 allele in the beta(3)-AR gene may predispose patients to higher serum uric acid level.

语种: 英语
WOS记录号: WOS:000178323300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50132
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.Beijing Univ, Hosp 3, Dept Endocrinol, Beijing 100083, Peoples R China
2.Harvard Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA

Recommended Citation:
Wang, GY,Li, QF,Niu, TH,et al. Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus[J]. CHINESE MEDICAL JOURNAL,2002,115(9):1308-1311.
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