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Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus
Wang, GY1; Li, QF1; Niu, TH1; Chen, CZ1; Xu, XP1
关键词Muscle Glycogen Synthase Gene Beta(3)-adrenergic Receptor Gene Type 2 Diabetes Mellitus Postprandial Glucose Serum Uric Acid
刊名CHINESE MEDICAL JOURNAL
2002-09-01
115期:9页:1308-1311
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]GLYCOGEN-SYNTHASE GENE ; INSULIN-RESISTANCE ; POLYMORPHISM
英文摘要

Objective To determine the relationships of Met416Val and Xbal polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the beta(3)-adrenergic-receptor (beta(3)-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population.

Methods Polymerase chain reaction-oligonucleotide ligation assay and restriction fragment length polymorphism assay were used to evaluate the GYS1 and beta(3)-AR gene polymorphisms in 102 pairs of case-control Chinese spouses.

Results Subjects with Met416Val variant had a significantly higher 2-hour post-glucose level than subjects without this variant had in diabetic group (P = 0.032). The Met416Val polymorphism of GYS1 gene was not significantly associated with the risk of type 2 DM (adjusted OR = 1.67; 95% Cl: 0.73 - 3.81, P = 0.223). Subjects with Trp64Arg variant had a significantly higher serum uric acid level than subjects without this variant had in diabetic group (P = 0. 034). The combination of BMI and Arg64 allele carrier of the beta(3)-AR gene increased the diabetic risk over four-fold (adjusted OR = 4.00; 95% Cl: 1.53 - 10.45, P = 0.005).

Conclusions In the Chinese population, Met416Val polymorphism is identified in a subgroup of diabetic subjects with high 2-hour post-glucose. It will explain why some diabetic patients appear to be genetically predisposed to developing high postpradial glucose level. The presence of the Arg64 allele in the beta(3)-AR gene may predispose patients to higher serum uric acid level.

语种英语
WOS记录号WOS:000178323300006
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50132
专题北京大学第三临床医学院_内分泌科
北京大学口腔医学院_医学装备处
作者单位1.Beijing Univ, Hosp 3, Dept Endocrinol, Beijing 100083, Peoples R China
2.Harvard Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
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GB/T 7714
Wang, GY,Li, QF,Niu, TH,et al. Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus[J]. CHINESE MEDICAL JOURNAL,2002,115(9):1308-1311.
APA Wang, GY,Li, QF,Niu, TH,Chen, CZ,&Xu, XP.(2002).Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus.CHINESE MEDICAL JOURNAL,115(9),1308-1311.
MLA Wang, GY,et al."Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus".CHINESE MEDICAL JOURNAL 115.9(2002):1308-1311.
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