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学科主题: 临床医学
题名:
Increasing body mass index identifies Chinese patients with type 2 diabetes mellitus at risk of poor outcomes
作者: Ji, Linong1; Zou, Dajin2; Liu, Li3; Qian, Lei3; Kadziola, Zbigniew4; Babineaux, Steven5; Zhang, He Na3; Wood, Robert6
关键词: Body mass index ; China ; Diabetes mellitus ; Obesity ; Quality of life
刊名: JOURNAL OF DIABETES AND ITS COMPLICATIONS
发表日期: 2015-05-01
DOI: 10.1016/j.jdiacomp.2015.02.014
卷: 29, 期:4, 页:488-496
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: FOLLOW-UP ; OBESITY ; INSULIN ; NIDDM ; PARTICIPANTS ; POPULATION ; PREVALENCE ; OVERWEIGHT ; PREVENTION ; MANAGEMENT
英文摘要:

Aims: Association between body mass index (BMI) and glycemic control, comorbidities/complications, and health-related quality of life (HRQoL) was assessed in Chinese patients with type 2 diabetes mellitus (T2DM) enrolled in the Diabetes Disease Specific Programme.

Methods: Surveys of 200 physicians and 2052 patients with T2DM captured demographic, clinical, and HRQoL information. Adjusted and unadjusted analyses were conducted across 3 BMI groups; normal (18.5-<24.0, n = 998), overweight (24.0-<28.0, n = 822), and obese (>= 28.0, n = 212).

Results: There were no between group differences in the achievement of glycated hemoglobin (HbA1c) <7.0% (48 mmol/mol); however, compared with the normal BMI group, more obese patients had an HbA1c >9.0% (75 mmol/mol; 4.3% vs 10.2%, P = 0.002). More obese patients compared with normal BMI patients had hypertension (48.6% vs 35.3%, P < 0.001), dyslipidemia (35.4% vs 18.8%, P < 0.001), or both hypertension and dyslipidemia (24.1% vs 13.9%, P < 0.001). Patients in the obese group reported worse HRQoL and greater effects of diabetes on their daily living.

Conclusions: Obesity in Chinese patients with T2DM results in poor glycemic control, more comorbidities, and worse HRQoL. Management of these patients should include efforts to reduce weight. Selection of weight-neutral or weight-reducing anti-diabetic medications maybe useful in these patients. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: Lilly Suzhou Pharmaceutical Company Ltd.
WOS记录号: WOS:000354157700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50133
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
2.2nd Mil Med Univ, Affiliated Changhai Hosp, Dept Endocrinol, Shanghai, Peoples R China
3.Lilly Suzhou Pharmaceut Co Ltd, Div Med, Shanghai 200021, Peoples R China
4.Eli Lilly & Co, Real World Analyt, Vienna, Austria
5.Eli Lilly & Co, Indianapolis, IN 46285 USA
6.Adelphi Real World, Bollington, Cheshire, England

Recommended Citation:
Ji, Linong,Zou, Dajin,Liu, Li,et al. Increasing body mass index identifies Chinese patients with type 2 diabetes mellitus at risk of poor outcomes[J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS,2015,29(4):488-496.
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