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学科主题基础医学
Kindlin-2 promotes genome instability in breast cancer cells
Zhao, Ting1,2,3; Guan, Lizhao1,2; Yu, Yu1,2; Pei, Xuelian1,2; Zhan, Jun1,2; Han, Ling4; Tang, Yan1,2; Li, Feng1,2; Fang, Weigang1,3; Zhang, Hongquan1,2
关键词Kindlin-2 Breast cancer Genome instability Tumor formation
刊名CANCER LETTERS
2013-04-28
DOI10.1016/j.canlet.2012.11.043
330期:2页:208-216
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]MITOGEN-INDUCIBLE GENE-2 ; CHINESE-HAMSTER CELLS ; MATRIX ADHESION ; NERVOUS-SYSTEM ; ANEUPLOIDY ; INTEGRINS ; INVASION ; TUMORS ; MIG-2 ; LYMPHOCYTES
英文摘要

Kindlin-2, as a focal adhesion protein, has been found to regulate tumor progression. However, the mechanism underlying Kindlin-2 regulation of tumor progression is largely unknown. Here, we report that Kindlin-2 regulates breast cancer cell proliferation, apoptosis and chromosomal abnormalities in both gain and loss of function assays. Functionally, overexpression of Kindlin-2 promotes tumor formation in implanted xenograft while knockdown of Kindlin-2 inhibits tumor growth in mice. Mechanistically, an array-based comparative genomic hybridization and karyotype analyses indicate that ectopic expression of Kindlin-2 leads to genome instability in breast cancer cells. Our data suggest a novel mechanism that Kindlin-2 regulates breast cancer progression by inducing genome instability. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000315308000010
项目编号2010CB912203 ; 2010CB529402 ; 30830048 ; 31170711 ; 81230051 ; 81101495 ; 7120002 ; BMU20120314
资助机构MSTC ; NSFC ; "111 Project" from Ministry of Education of China ; Beijing Natural Science Foundation ; Leading Academic Discipline Project of Beijing Education Bureau
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50134
专题北京大学基础医学院_病理学系
北京大学医学部管理机构_主任办公室党委办公室
北京大学基础医学院
北京大学药学院_药学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Anat Histol & Embryol, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.Peking Univ, Dept Med Genet, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Ting,Guan, Lizhao,Yu, Yu,et al. Kindlin-2 promotes genome instability in breast cancer cells[J]. CANCER LETTERS,2013,330(2):208-216.
APA Zhao, Ting.,Guan, Lizhao.,Yu, Yu.,Pei, Xuelian.,Zhan, Jun.,...&Zhang, Hongquan.(2013).Kindlin-2 promotes genome instability in breast cancer cells.CANCER LETTERS,330(2),208-216.
MLA Zhao, Ting,et al."Kindlin-2 promotes genome instability in breast cancer cells".CANCER LETTERS 330.2(2013):208-216.
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