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学科主题: 口腔医学
题名:
The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?
作者: Li, T. -J.1,2
关键词: odontogenic keratocyst ; keratocystic odontogenic tumor ; Gorlin syndrome ; PTCH1 ; Hedgehog signaling pathway
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2011-02-01
DOI: 10.1177/0022034510379016
卷: 90, 期:2, 页:133-142
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: BASAL-CELL CARCINOMA ; TUMOR-SUPPRESSOR GENE ; GORLIN-SYNDROME ; NEVUS SYNDROME ; GERMLINE MUTATIONS ; SIGNALING PATHWAY ; AGGRESSIVE NATURE ; HEDGEHOG PATHWAY ; PTCH MUTATIONS ; HUMAN HOMOLOG
英文摘要:

The odontogenic keratocyst (OKC, currently designated by the World Health Organization as a keratocystic odontogenic tumor) is a locally aggressive, cystic jaw lesion with a putative high growth potential and a propensity for recurrence. Although it is generally agreed that some features of OKCs are those of a neoplasia, notably the relatively high proliferative rate of epithelial cells, controversies over the behavior and management of OKCs still exist. This article is intended to review this intriguing entity and to summarize the findings of recent studies related to the nature of OKCs and their clinical and therapeutic implications. Recent advances in genetic and molecular research, i.e., PTCH1 mutations and involvement of the Hedgehog signaling pathway, have led to increased knowledge of OKC pathogenesis which hints at potential new treatment options, although the question of whether the OKC is a cyst or a cystic neoplasm is yet to be answered with certainty. Since some advocate a more conservative treatment for OKCs, notably marsupialization and decompression, future treatment strategies may focus on molecular approaches and eventually reduce or eliminate the need for aggressive surgeries.

语种: 英语
所属项目编号: 30872900 ; 30625044 ; 30572048
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000286598100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50139
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China

Recommended Citation:
Li, T. -J.. The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?[J]. JOURNAL OF DENTAL RESEARCH,2011,90(2):133-142.
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