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The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?
Li, T. -J.1,2
关键词Odontogenic Keratocyst Keratocystic Odontogenic Tumor Gorlin Syndrome Ptch1 Hedgehog Signaling Pathway
刊名JOURNAL OF DENTAL RESEARCH
2011-02-01
DOI10.1177/0022034510379016
90期:2页:133-142
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Nature Science Foundation of China ; National Nature Science Foundation of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]BASAL-CELL CARCINOMA ; TUMOR-SUPPRESSOR GENE ; GORLIN-SYNDROME ; NEVUS SYNDROME ; GERMLINE MUTATIONS ; SIGNALING PATHWAY ; AGGRESSIVE NATURE ; HEDGEHOG PATHWAY ; PTCH MUTATIONS ; HUMAN HOMOLOG
英文摘要

The odontogenic keratocyst (OKC, currently designated by the World Health Organization as a keratocystic odontogenic tumor) is a locally aggressive, cystic jaw lesion with a putative high growth potential and a propensity for recurrence. Although it is generally agreed that some features of OKCs are those of a neoplasia, notably the relatively high proliferative rate of epithelial cells, controversies over the behavior and management of OKCs still exist. This article is intended to review this intriguing entity and to summarize the findings of recent studies related to the nature of OKCs and their clinical and therapeutic implications. Recent advances in genetic and molecular research, i.e., PTCH1 mutations and involvement of the Hedgehog signaling pathway, have led to increased knowledge of OKC pathogenesis which hints at potential new treatment options, although the question of whether the OKC is a cyst or a cystic neoplasm is yet to be answered with certainty. Since some advocate a more conservative treatment for OKCs, notably marsupialization and decompression, future treatment strategies may focus on molecular approaches and eventually reduce or eliminate the need for aggressive surgeries.

语种英语
所属项目编号30872900 ; 30625044 ; 30572048
资助者National Nature Science Foundation of China ; National Nature Science Foundation of China
WOS记录号WOS:000286598100001
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50139
专题北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
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GB/T 7714
Li, T. -J.. The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?[J]. JOURNAL OF DENTAL RESEARCH,2011,90(2):133-142.
APA Li, T. -J..(2011).The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?.JOURNAL OF DENTAL RESEARCH,90(2),133-142.
MLA Li, T. -J.."The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?".JOURNAL OF DENTAL RESEARCH 90.2(2011):133-142.
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