IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科
学科主题口腔医学
The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?
Li, T. -J.1,2
关键词Odontogenic Keratocyst Keratocystic Odontogenic Tumor Gorlin Syndrome Ptch1 Hedgehog Signaling Pathway
刊名JOURNAL OF DENTAL RESEARCH
2011-02-01
DOI10.1177/0022034510379016
90期:2页:133-142
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]BASAL-CELL CARCINOMA ; TUMOR-SUPPRESSOR GENE ; GORLIN-SYNDROME ; NEVUS SYNDROME ; GERMLINE MUTATIONS ; SIGNALING PATHWAY ; AGGRESSIVE NATURE ; HEDGEHOG PATHWAY ; PTCH MUTATIONS ; HUMAN HOMOLOG
英文摘要

The odontogenic keratocyst (OKC, currently designated by the World Health Organization as a keratocystic odontogenic tumor) is a locally aggressive, cystic jaw lesion with a putative high growth potential and a propensity for recurrence. Although it is generally agreed that some features of OKCs are those of a neoplasia, notably the relatively high proliferative rate of epithelial cells, controversies over the behavior and management of OKCs still exist. This article is intended to review this intriguing entity and to summarize the findings of recent studies related to the nature of OKCs and their clinical and therapeutic implications. Recent advances in genetic and molecular research, i.e., PTCH1 mutations and involvement of the Hedgehog signaling pathway, have led to increased knowledge of OKC pathogenesis which hints at potential new treatment options, although the question of whether the OKC is a cyst or a cystic neoplasm is yet to be answered with certainty. Since some advocate a more conservative treatment for OKCs, notably marsupialization and decompression, future treatment strategies may focus on molecular approaches and eventually reduce or eliminate the need for aggressive surgeries.

语种英语
WOS记录号WOS:000286598100001
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50139
Collection北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Li, T. -J.. The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?[J]. JOURNAL OF DENTAL RESEARCH,2011,90(2):133-142.
APA Li, T. -J..(2011).The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?.JOURNAL OF DENTAL RESEARCH,90(2),133-142.
MLA Li, T. -J.."The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?".JOURNAL OF DENTAL RESEARCH 90.2(2011):133-142.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Li, T. -J.]'s Articles
百度学术
百度学术Similar articles in
[Li, T. -J.]'s Articles
必应学术
必应学术Similar articles in
[Li, T. -J.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.