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学科主题: 临床医学
题名:
Development of a Biomedical Micro/Nano Robot for Drug Delivery
作者: Zhang, Zhenhai1; Li, Zhifei2; Yu, Wei3; Li, Kejie1; Xie, Zhihong4
关键词: Micro/Nano Robot ; Bacterial Flagellar Motor ; Liposome ; Antibody ; Drug Delivery System
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
发表日期: 2015-04-01
DOI: 10.1166/jnn.2015.9643
卷: 15, 期:4, 页:3126-3129
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: FLAGELLA ; MOTOR
英文摘要:

Flagellated bacteria have been utilized as potential swimming micro-robotic bodies for propulsion of spherical liposome by attaching several bacteria on their surface. Liposome as a drug delivery vehicle can contain biologically active compounds. In this work, the antibody binding technique is developed to attach bacteria to liposome′s surface. Consequently, the stochastic effect of bacterial propulsion of liposome is investigated analytically and experimentally. It is shown that the mobility of liposome with bacteria was higher than that of liposome without bacteria. Experimental data matches well with statistical calculation.

语种: 英语
所属项目编号: 61273346 ; 31370108 ; 51106093 ; 50876058 ; 1103000003 ; 2013JH021 ; C x x 20110003 ; A x x 20110005 ; A x x 20132010 ; 20121101120009 ; 2012YG0203 ; 2013CX04031 ; 2011CX02023 ; 2014CX x x x x ; B08043
项目资助者: National Natural Science Foundation of China ; Hundred Talents Program of Chinese Academy of Sciences ; Key Projects in the Yantai Science and Technology Pillar Program ; National Defense Major Fundamental Research Program of China ; National Defense Key Fundamental Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, Excellent Young Scholars Research Fund of Beijing Institute of Technology ; Program for the Fundamental Research of Beijing Institute of Technology ; Program of Introducing Talents of Discipline to University, China
WOS记录号: WOS:000347435100080
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50140
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Beijing Inst Technol, Sch Mechatron Engn, Beijing 100081, Peoples R China
2.Peking Univ, Dept Gen Surg, Hosp 3, Beijing 100191, Peoples R China
3.Shanghai Second Polytech Univ, Sch Urban Dev & Environm Engn, Shanghai 201209, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China

Recommended Citation:
Zhang, Zhenhai,Li, Zhifei,Yu, Wei,et al. Development of a Biomedical Micro/Nano Robot for Drug Delivery[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2015,15(4):3126-3129.
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