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学科主题: 临床医学
题名:
Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma
作者: Wang Jing-yu2; Xu Xiao-yuan2; Jia Jing-hui1; Wu Chi-hong2; Ge Ruo-wen1
关键词: hepatocellular carcinoma ; tumor angiogenesis ; endothelial cell ; immunohistochemistry ; enzyme-linked immunosorbent assay
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-03-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.06.017
卷: 123, 期:6, 页:730-733
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ENDOGLIN CD105 ; PROGNOSTIC MARKERS ; GROWTH-FACTOR ; ANGIOGENESIS ; CANCER ; ESOPHAGUS
英文摘要:

Background Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. In order to investigate the molecular biologic mechanism of HCC′s development, we studied the expressions of SE-1, CD105 and CD31 in tumor endothelial cells (TECs) of HCC and in the serum of rats.

Methods We analyzed the expressions of SE-1, CD31 and CD105 in rat HCC tumor tissues using immunohistochemistry (IHC). Twenty HCC bearing rats and eighteen normal rats were examined for the expressions of SE-1, CD31 and CD105 antigens in serum by enzyme-linked immunosorbent assay (ELISA).

Results SE-1, CD31 and CD105 antigens were detected both in HCC tissue and in normal liver tissue with higher expressions of CD31 and CD105 in HCC while the SE-1 antigen expression was higher in normal liver. Similarly, serum CD31 and CD105 in rats with HCC were significantly increased compared with normal rats (t=2.8628, P=0.0086; t=4.4922, P <0.0001, respectively). In contrast, SE-1 antigen in HCC rat serum was significantly decreased compared with normal rats (t=3.4983, P=0.0011).

Conclusion SE-1, CD31 and CD105 are closely related with liver tumor angiogenesis, which is similar to their performances in terms of their expressions in the serum. Chin Med J 2010;123(6):730-733

语种: 英语
WOS记录号: WOS:000276230600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50150
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
2.Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Wang Jing-yu,Xu Xiao-yuan,Jia Jing-hui,et al. Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma[J]. CHINESE MEDICAL JOURNAL,2010,123(6):730-733.
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