学科主题临床医学
Association between vascular endothelial growth factor gene promoter polymorphisms and sporadic amyotrophic lateral sclerosis in a Han Chinese population Case-control study
Sui, Wei1; Liu, Na1; Zhang, Nan1; Zhang, Jun1; Wang, Liping1; Zhang, Xiaoyan2; Zhang, Huagang1; Li, Lingsong2; Chen, Dafang3; Fan, Dongsheng1
关键词Amyotrophic Lateral Sclerosis Genetic Polymorphisms Vascular Endothelial Growth Factor
刊名NEURAL REGENERATION RESEARCH
2009-12-01
DOI10.3969/j.issn.1673-5374.2009.12.025
4期:12页:1110-1115
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]MOTOR-NEURON DEGENERATION ; FACTOR VEGF GENE ; PROLONGS SURVIVAL ; IN-VITRO ; ALS ; HYPOXIA ; MECHANISMS ; EXPRESSION ; DELETION ; MODEL
英文摘要

BACKGROUND: Studies have shown that vascular endothelial growth factor (VEGF) gene polymorphisms highly correlate with sporadic amyotrophic lateral sclerosis (ALS), although this remains controversial. To date, the relationship between VEGF gene polymorphism and sporadic ALS in a Han Chinese population remains unclear.

OBJECTIVE: To explore the relationship between sporadic ALS and VEGF gene promoter 7 locus polymorphisms in a Han Chinese population, and to investigate whether this relationship exhibits gender differences.

DESIGN, TIME AND SETTING: A case-control study regarding genetic association was performed at the Central Laboratory of Peking University Third Hospital from 2002 to 2006.

PARTICIPANTS: A total of 93 patients, who were diagnosed with definite or probable ALS according to El Escorial-revised diagnostic criteria, were selected from the Outpatient Department of Neurology, Peking University Third Hospital from 2002 to 2006. All patients were from Han populations, with no family history of ALS. In addition, 103 gender- and age-matched healthy volunteers were selected as controls.

METHODS: Peripheral venous blood was collected, and whole blood genomic DNA was extracted. VEGF gene promoter 7 locus polymorphisms were analyzed by PCR using the fluorescent Taqman system. The relationship between VEGF gene promoter single nucleotide polymorphisms and ALS was analyzed using Logistic regression model analysis and was stratified according to gender.

MAIN OUTCOME MEASURES: 7 VEGF gene promoter polymorphisms genotype distribution and allele frequencies.

RESULTS: There were no significant differences in VEGF gene promoter 7 locus genotype distribution and allele frequency between case and control groups (P > 0.05). Stratified analysis based on gender demonstrated that female Han subjects carrying the VEGF genotype -1154AA, -2549TT, -634CC genotype were more susceptible to ALS than those carrying -1154GG, -2549CC, -634GG (VEGF-1154AA: OR = 8.9,95%CI = 1.0-77.3, P = 0.047; VEGF-2549TT: OR = 3.1, 95% CI = 1.0-9.6, P = 0.049, VEGF-634CC: OR = 0.2, 95%CI = 0.1-0.7, P = 0.012). Moreover, in female Han populations, people carrying allele -1154A, -2549T, -634C exhibited an increased risk of ALS (VEGF -1154A: OR = 2.3,95%CI = 1.2-4.5, P = 0.018; VEGF-2549T: OR = 3.1, 95%CI = 1.4-6.9, P = 0.005; VEGF-634C: OR = 0.5, 95%CI = 0.3-0.9, P = 0.015).

CONCLUSION: Results showed that VEGF 7 gene promoter polymorphisms were associated with ALS in Han Chinese women. The VEGF gene -1154A, -2549T, -634C allele and -1154AA, -2549TT, -634CC genotype could function as susceptibility genes for ALS in Han Chinese women.

语种英语
WOS记录号WOS:000273468500025
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50156
专题北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学基础医学院
北京大学第三临床医学院_神经内科
作者单位1.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
2.Peking Univ, Stem Cell Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Dept Epidemiol & Stat, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sui, Wei,Liu, Na,Zhang, Nan,et al. Association between vascular endothelial growth factor gene promoter polymorphisms and sporadic amyotrophic lateral sclerosis in a Han Chinese population Case-control study[J]. NEURAL REGENERATION RESEARCH,2009,4(12):1110-1115.
APA Sui, Wei.,Liu, Na.,Zhang, Nan.,Zhang, Jun.,Wang, Liping.,...&Fan, Dongsheng.(2009).Association between vascular endothelial growth factor gene promoter polymorphisms and sporadic amyotrophic lateral sclerosis in a Han Chinese population Case-control study.NEURAL REGENERATION RESEARCH,4(12),1110-1115.
MLA Sui, Wei,et al."Association between vascular endothelial growth factor gene promoter polymorphisms and sporadic amyotrophic lateral sclerosis in a Han Chinese population Case-control study".NEURAL REGENERATION RESEARCH 4.12(2009):1110-1115.
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