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学科主题: 临床医学
题名:
Common Genetic Variants in the Chromogranin A Promoter Are Associated with Renal Injury in IGA Nephropathy Patients with Malignant Hypertension
作者: Yu, L.; Jiang, L.; Zhou, X. J.; Zhu, L.; Zhang, H.
关键词: Chromogranin A ; IgA nephropathy ; Malignant hypertension ; Polymorphism ; Renal function
刊名: RENAL FAILURE
发表日期: 2010
DOI: 10.3109/08860220903377597
卷: 32, 期:1, 页:41-46
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; CATECHOLAMINE RELEASE ; LINKAGE PHASE ; POLYMORPHISMS ; TESTS
英文摘要:

The present study aimed to investigate whether genetic variants in the chromogranin A (CHGA) promoter were associated with malignant hypertension (MHT) and renal functional damage. The polymorphisms of CHGA promoter in 39 patients with malignant hypertension secondary to idiopathic IgA nephropathy (IgAN-MHT), 23 patients with primary malignant hypertension and 63 controls were genotyped by sequencing. Four diploid genotypes with minor allele frequencies of approximately >= 10% for individual CHGA SNP loci or haplotypes were compared among the patient with IgAN-MHT, primary MHT and healthy control. Polymorphisms and haplotypes of CHGA promoter were not associated with primary MHT and IgAN-MHT. Within 39 IgAN-MHT patients whose clinical and histological data were available, patients carrying -415TT genotype tended to present with higher serum creatinine (Scr) level than those carrying -415TC/CC genotype (636.94 +/- 524.07 mu mol/L vs 277.84 +/- 196.39 mu mol/L, P = 0.014). Consistent with this statistic, we found the haplotype-specific score value of haplotype ATC was 2.25046 (p = 0.024), and by permutation testing, the empirical p value was 0.014. The present study suggested the genetic variants in the chromogranin A promoter may not involve in the onset of malignant hypertension, but the variants might play a role in the renal dysfunction in patients with IgAN-MHT.

语种: 英语
所属项目编号: 30670981 ; 30825021 ; 200802052
项目资助者: NSCF ; Foundation of Ministry of Health of China
WOS记录号: WOS:000277745400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50157
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Div Renal, Hosp 1, Inst Nephrol,Key Lab Renal Dis,Minist Hlth China, Beijing 100034, Peoples R China

Recommended Citation:
Yu, L.,Jiang, L.,Zhou, X. J.,et al. Common Genetic Variants in the Chromogranin A Promoter Are Associated with Renal Injury in IGA Nephropathy Patients with Malignant Hypertension[J]. RENAL FAILURE,2010,32(1):41-46.
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