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学科主题临床医学
Echocardiographic assessment of beta-adrenoceptor stimulation-induced heart failure with reduced heart rate in mice
Li, Hao1,2,3; Lu, Zhi-Zhen1,2,3; Chen, Chao1,2,3; Song, Yao1,2,3; Xiao, Han1,2,3; Zhang, You-Yi1,2,3
关键词Adrenoceptor Echocardiography Heart Failure Heart Rate Isoflurane
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2014
DOI10.1111/1440-1681.12176
41期:1页:58-66
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]CARDIAC-HYPERTROPHY ; MYOCARDIAL-INFARCTION ; SIGNALING PATHWAY ; NERVOUS-SYSTEM ; ISOPROTERENOL ; ACTIVATION ; DISRUPTION ; ANESTHESIA ; FIBROSIS ; DISEASE
英文摘要

Chronic injection with the -adrenoceptor (-AR) agonist isoproterenol (ISO) has been commonly used as an animal model of -AR-induced cardiac remodelling and heart failure. This ISO-treated model usually exhibits significantly decreased conscious heart rate (HR). However, the HR in treatment groups is usually adjusted to the same levels by anaesthesia to assess cardiac geometry and function. In the present study, we report a method of echocardiographic assessment that represents the true cardiac geometry and function under conditions of ISO withdrawal. Briefly, C57BL/6 mice were treated with 5mg/kg per day ISO for 12weeks. Cardiac geometry and function were assessed by high-resolution echocardiography in vehicle (saline) - and ISO-treated mice that were either conscious or anaesthetized using different concentrations of isoflurane. The cardiac -AR response was decreased in ISO-treated mice, as evidenced by markedly decreased conscious HR. Vehicle- and ISO-treated mice did not differ in terms of cardiac geometry or function when HR was adjusted to the same level (400b.p.m.) in both treatment groups, but cardiac geometry and function did differ when a low (1%) rather than high (1.5% or 2%) isoflurane concentration was used to adjust HR. Furthermore, 3day ISO withdrawal eliminated the difference in conscious HR between the two groups. In addition, the groups differed in cardiac geometry and function regardless of the isoflurane concentration used. In conclusion, using isoflurane to decrease the HR of treated groups to the same level may mask left ventricular dysfunction in ISO-treated mice. Withdrawal of ISO eliminated the difference in basal HR between the ISO-treated and control groups on echocardiography, allowing a more accurate assessment of cardiac pathological and functional changes.

语种英语
WOS记录号WOS:000329140400009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50161
专题北京大学精神卫生研究所_精神科
北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ Third Hosp, Inst Vasc Med, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Cardiovasc Mol Biologyand Regulatory Pept, Beijing, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Hao,Lu, Zhi-Zhen,Chen, Chao,et al. Echocardiographic assessment of beta-adrenoceptor stimulation-induced heart failure with reduced heart rate in mice[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2014,41(1):58-66.
APA Li, Hao,Lu, Zhi-Zhen,Chen, Chao,Song, Yao,Xiao, Han,&Zhang, You-Yi.(2014).Echocardiographic assessment of beta-adrenoceptor stimulation-induced heart failure with reduced heart rate in mice.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,41(1),58-66.
MLA Li, Hao,et al."Echocardiographic assessment of beta-adrenoceptor stimulation-induced heart failure with reduced heart rate in mice".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41.1(2014):58-66.
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