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学科主题: 临床医学
题名:
Gender differences are associated with the clinical features of systemic lupus erythematosus
作者: Ding Yan; He Jing; Guo Jian-ping; Dai Yi-jun; Li Chun; Feng Min; Li Ru; Li Zhan-guo
关键词: systemic lupus erythematosus ; male lupus ; gender
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-07-20
DOI: 10.3760/cma.j.issn.0366-6999.2012.14.015
卷: 125, 期:14, 页:2477-2481
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MALES ; DISEASE ; RISK ; POPULATION ; MORBIDITY ; MICE
英文摘要:

Background Systemic lupus erythematosus (SLE) mostly occurred in young women. This study was undertaken to investigate the different clinical characteristics of SLE between male and female patients, and to identify the sex hormone levels and clinical outcomes of different gender in SLE patients.

Methods Of the 516 SLE patients admitted to the Peking University People′s Hospital from January 2008 to December 2010, 58 were male and 458 were female. Clinical manifestations, laboratory profiles and disease activity scores were evaluated in male and female patients. Sex hormones levels were also compared among male patients.

Results The median age at SLE onset in male and female patients was 27.2 and 28.6 years, respectively. Compared with female patients, at onset of SLE, male patients showed higher rates of serious renal disease (58.6% vs. 47.2%, P=0.064), neuropsychiatric SLE (20.7% vs. 12.0%, P=0.055), and a higher incidence of anti-ds-DNA (25.9% vs. 16.8%, P=0.069), anti-Sm (17.2% vs. 8.7%, P=0.002), anti-Ro (46.6% vs. 28.4%, P=0.004), anti-U1RNP (29.3% vs. 15.3%, P=0.010), anticardiolipin antibody (25.9% vs. 11.4%, P=0.004), and decreased C3 levels (67.2% vs. 49.8%, P=0.009). Systemic lupus erythematosus disease activity index (SLEDAI) scores were higher in men than in women (16.8 vs. 12.8, P=0.038). Of the 58 male patients, 24 had not received aggressive treatment during the three months prior to the study. Levels of testosterone and dihydroepiandrosterone (DHEA) were lower in male SLE patients than in male healthy controls (P=0.004 and P=0.006, respectively). Low serum testosterone was an independent risk factor for the development of lupus nephritis (P=0.043). Male patients with elevated serum prolactin were at increased risk of developing neuropsychiatric manifestations of SLE (P=0.081).

Conclusion Early recognition of risk factors and appropriate intervention are essential, which might lead to high disease activity and serious systemic damage in male SLE patients. Chin Med J 2012;125(14):2477-2481

语种: 英语
所属项目编号: 7102155 ; 31070788
项目资助者: Beijing Natural Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000307677600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50162
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Ding Yan,He Jing,Guo Jian-ping,et al. Gender differences are associated with the clinical features of systemic lupus erythematosus[J]. CHINESE MEDICAL JOURNAL,2012,125(14):2477-2481.
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