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学科主题临床医学
Expression of nephrin, podocin, alpha-actinin, and WT1 in children with nephrotic syndrome
Guan, N1; Ding, J1; Zhang, JJ1; Yang, JY1
关键词Nephrotic Syndrome Proteinuria Podocyte Nephrin Podocin Alpha-actinin Wt1
刊名PEDIATRIC NEPHROLOGY
2003-11-01
DOI10.1007/s00467-003-1240-z
18期:11页:1122-1127
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics ; Urology & Nephrology
研究领域[WOS]Pediatrics ; Urology & Nephrology
关键词[WOS]FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; GLOMERULAR SLIT DIAPHRAGM ; KIDNEY-DISEASES ; PODOCYTES ; PROTEIN ; MUTATIONS ; JUNCTION ; SYNAPTOPODIN ; CYTOSKELETON ; CONTRACTILE
英文摘要

Recently, nephrin, podocin, alpha-actinin, and WT1, which are located at the slit diaphragm and expressed by the podocyte, were found to be causative in congenital/familial nephrotic syndrome (NS), but their role in acquired NS remains unclear. We studied their expression in NS with the aim of disclosing their possible role in the development of proteinuria. Immunofluorescence, confocal microscopy, and image analysis were used to study the expression and the distribution in 19 children with primary NS, 9 with isolated hematuria, and 9 controls. All the children with NS presented with heavy proteinuria and foot process effacement was identified by electron microscopy. No proteinuria and foot process effacement was seen in the group with hematuria. A dramatic decrease of podocin expression was found in NS (86.66+/-22.74) compared with control groups (P=0.014). Furthermore, we also found the pattern of distribution of nephrin, podocin, and alpha-actinin changed in children with NS. In conclusion, a dramatic decrease of podocin expression and abnormal distribution of nephrin, podocin, and alpha-actinin were found in children with NS. No differences were found in children with isolated hematuria, suggesting involvement of these molecules in the development of proteinuria in primary NS.

语种英语
WOS记录号WOS:000186244100007
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50164
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing, Peoples R China
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GB/T 7714
Guan, N,Ding, J,Zhang, JJ,et al. Expression of nephrin, podocin, alpha-actinin, and WT1 in children with nephrotic syndrome[J]. PEDIATRIC NEPHROLOGY,2003,18(11):1122-1127.
APA Guan, N,Ding, J,Zhang, JJ,&Yang, JY.(2003).Expression of nephrin, podocin, alpha-actinin, and WT1 in children with nephrotic syndrome.PEDIATRIC NEPHROLOGY,18(11),1122-1127.
MLA Guan, N,et al."Expression of nephrin, podocin, alpha-actinin, and WT1 in children with nephrotic syndrome".PEDIATRIC NEPHROLOGY 18.11(2003):1122-1127.
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