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学科主题: 药学
题名:
High-performance liquid chromatographic assay for the active saponins from Panax notoginseng in rat tissues
作者: Zhang, JL1; Li, L1; Sheng, YX1; Wang, SS1; Guo, DA1
关键词: Panax notoginseng ; ginsenosides ; tissue distribution ; pharmacokinetics
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2006-04-01
DOI: 10.1002/bmc.567
卷: 20, 期:4, 页:327-335
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: GINSENG SAPONINS ; METABOLISM ; ABSORPTION ; EXCRETION ; RG(1) ; RB-1 ; RG1
英文摘要:

A reversed-phase liquid chromatographic method was used to determine the ginsenosides Rg(1), Rb-1 and Rd of Panax notoginseng in rat tissues (kidney, liver, heart, spleen and lung) after the administration of total saponins of P. notoginseng. The tissue samples were treated with solid-phase extraction prior to HPLC. The calibration curves for the three saponins were linear in the given concentration ranges. The intra-day and inter-day assay coefficients in tissues were between 76 and 120% respectively. The recoveries of all the tissues were higher than 70%. This method was applied to evaluate the distribution of the three major saponins of P. notoginseng in rat tissues. Copyright (c) 2005 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000237238200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50169
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, JL,Li, L,Sheng, YX,et al. High-performance liquid chromatographic assay for the active saponins from Panax notoginseng in rat tissues[J]. BIOMEDICAL CHROMATOGRAPHY,2006,20(4):327-335.
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