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学科主题: 基础医学
题名:
Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice
作者: Pan, Chun Shui1; Zhang, Jing4; Yu, Fang2; Teng, Xu1; Cao, Chang Qi1; Wu, Wei1; Tang, Chao Shu1,2,3; Qi, Yong Fen1,2,3
关键词: Adrenomedullin ; Atherosclerosis ; Calcitonin receptor-like receptor ; Receptor activity-modifying proteins ; ApoE-/- mice
刊名: PEPTIDES
发表日期: 2010-06-01
DOI: 10.1016/j.peptides.2010.03.005
卷: 31, 期:6, 页:1150-1158
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: RECEPTOR-LIKE RECEPTOR ; SMOOTH-MUSCLE-CELLS ; INTIMA-MEDIA THICKNESS ; RAT ENDOTHELIAL-CELLS ; GENE-EXPRESSION ; CALCIFICATION ; SECRETION ; PROTEIN ; CARDIOMYOCYTES ; HYPERPLASIA
英文摘要:

Adrenomedullin (ADM) is a multifunctional peptide regulating cardiovascular homeostasis. We studied the role of ADM in the pathogenesis of atherosclerosis by investigating changes in ADM and its receptors - calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs) - in aorta of apoE-/- mice and the effect of exogenous ADM administration. ApoE-/- mice were fed an atherogenic diet for 4 weeks, and apoE-/-+ ADM mice were additionally given subcutaneous injections of ADM, 300 ng/kg/h, for 4 weeks. ApoE-/- mice fed an atherogenic diet showed hyperlipidemia, a large plaque area and increased vessel wall thickness. The mRNA expression and protein level of ADM/ADM receptors were increased in the aorta, compared with C57BL/6J mice. The elevated mRNA level of CRLR and RAMPs correlated positively with ADM mRNA level. Radioimmunoassay revealed a higher plasma and aorta ADM content, by 61.6% and 285% (both P < 0.01), respectively, in apoE-/- mice than that in C57BL/6J mice. Exogenous ADM significantly ameliorated dyslipidemia in apoE-/- mice. ADM-treated mice showed fewer aortic plaques, decreased plaque area, by 76% (P < 0.01), and reduced ratio of plaque area to luminal area, by 65% (P < 0.01), and ultrasonography revealed significantly reduced intima-media thickness of the ascending branch and abdominal aorta. The results suggest that atherosclerotic apoE-/- mice fed an atherogenic diet showed upregulated endogenous ADM and its receptors, and exogenous ADM treatment ameliorated the dyslipidemia and vascular atherosclerotic lesions. ADM/ADM receptors might be an important protective system against atherosclerosis and could become a new target of prevention and therapy for atherosclerosis. (C) 2010 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30871013 ; 30600232 ; 2006CB503807
项目资助者: National Natural Sciences Foundation of China ; Major Basic Research Development Program of the People&prime ; s Republic of China
WOS记录号: WOS:000283939000023
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50171
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
4.Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China

Recommended Citation:
Pan, Chun Shui,Zhang, Jing,Yu, Fang,et al. Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice[J]. PEPTIDES,2010,31(6):1150-1158.
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