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学科主题基础医学
Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice
Pan, Chun Shui1; Zhang, Jing4; Yu, Fang2; Teng, Xu1; Cao, Chang Qi1; Wu, Wei1; Tang, Chao Shu1,2,3; Qi, Yong Fen1,2,3
关键词Adrenomedullin Atherosclerosis Calcitonin Receptor-like Receptor Receptor Activity-modifying Proteins Apoe-/- Mice
刊名PEPTIDES
2010-06-01
DOI10.1016/j.peptides.2010.03.005
31期:6页:1150-1158
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]RECEPTOR-LIKE RECEPTOR ; SMOOTH-MUSCLE-CELLS ; INTIMA-MEDIA THICKNESS ; RAT ENDOTHELIAL-CELLS ; GENE-EXPRESSION ; CALCIFICATION ; SECRETION ; PROTEIN ; CARDIOMYOCYTES ; HYPERPLASIA
英文摘要

Adrenomedullin (ADM) is a multifunctional peptide regulating cardiovascular homeostasis. We studied the role of ADM in the pathogenesis of atherosclerosis by investigating changes in ADM and its receptors - calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs) - in aorta of apoE-/- mice and the effect of exogenous ADM administration. ApoE-/- mice were fed an atherogenic diet for 4 weeks, and apoE-/-+ ADM mice were additionally given subcutaneous injections of ADM, 300 ng/kg/h, for 4 weeks. ApoE-/- mice fed an atherogenic diet showed hyperlipidemia, a large plaque area and increased vessel wall thickness. The mRNA expression and protein level of ADM/ADM receptors were increased in the aorta, compared with C57BL/6J mice. The elevated mRNA level of CRLR and RAMPs correlated positively with ADM mRNA level. Radioimmunoassay revealed a higher plasma and aorta ADM content, by 61.6% and 285% (both P < 0.01), respectively, in apoE-/- mice than that in C57BL/6J mice. Exogenous ADM significantly ameliorated dyslipidemia in apoE-/- mice. ADM-treated mice showed fewer aortic plaques, decreased plaque area, by 76% (P < 0.01), and reduced ratio of plaque area to luminal area, by 65% (P < 0.01), and ultrasonography revealed significantly reduced intima-media thickness of the ascending branch and abdominal aorta. The results suggest that atherosclerotic apoE-/- mice fed an atherogenic diet showed upregulated endogenous ADM and its receptors, and exogenous ADM treatment ameliorated the dyslipidemia and vascular atherosclerotic lesions. ADM/ADM receptors might be an important protective system against atherosclerosis and could become a new target of prevention and therapy for atherosclerosis. (C) 2010 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000283939000023
项目编号30871013 ; 30600232 ; 2006CB503807
资助机构National Natural Sciences Foundation of China ; Major Basic Research Development Program of the People&prime ; s Republic of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50171
专题北京大学基础医学院
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
4.Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China
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GB/T 7714
Pan, Chun Shui,Zhang, Jing,Yu, Fang,et al. Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice[J]. PEPTIDES,2010,31(6):1150-1158.
APA Pan, Chun Shui.,Zhang, Jing.,Yu, Fang.,Teng, Xu.,Cao, Chang Qi.,...&Qi, Yong Fen.(2010).Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice.PEPTIDES,31(6),1150-1158.
MLA Pan, Chun Shui,et al."Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice".PEPTIDES 31.6(2010):1150-1158.
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