IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study
Zhu, Shi-guang21; Guo, Ming-ming1,2; Duan, Xue-ning3; Cui, Shu-de4; Tian, Fu-guo5; Cao, Xu-chen6; Geng, Cui-zhi7; Fan, Zhi-min8; Wang, Xiang9; Wang, Shu10; Jiang, Hong-chuan11; Zhang, Jian-guo12; Jin, Feng13; Tang, Jin-hai14; Liang, Hong15; Yang, Zhen-lin16; Wang, Hai-bo17; Wang, Qi-tang18; Li, Guo-lou19; Li, Liang20; Zuo, Wen-shu22; Liu, Li-yuan23; Wang, Lu24; Ma, Dan-dan1; Liu, Shu-chen1; Xiang, Yu-juan2; Liu, Lu1; Ye, Chun-miao1; Zhou, Wen-zhong1; Wang, Fei2; Yu, Li-xiang2; Ma, Zhong-bing2; Yu, Zhi-gang2
刊名PLOS ONE
2015-06-12
DOI10.1371/journal.pone.0129246
10期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]METAANALYSIS ; RECEPTORS ; COMPLEX ; PROTEIN ; WOMEN
英文摘要

The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed.

语种英语
WOS记录号WOS:000356327000057
项目编号ZR2014HZ004 ; BL2014055
资助机构Key Project of the Natural Science Foundation of Shandong Province, China ; Clinical Scientific Research Project of Science and Technology Agency of Jiangsu Province, China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50173
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Breast Dis Ctr, Beijing 100871, Peoples R China
2.Qingdao Cent Hosp, Qingdao Med Coll, Affiliated Hosp 2, Dept Breast Surg, Qingdao, Shandong, Peoples R China
3.Shandong Univ, Sch Med, Jinan 250100, Shandong, Peoples R China
4.Shandong Univ, Hosp 2, Dept Breast Surg, Jinan 250100, Shandong, Peoples R China
5.Zhengzhou Univ, Affiliated Tumor Hosp, Dept Breast Surg, Zhengzhou 450052, Henan, Peoples R China
6.Shanxi Canc Hosp, Dept Breast Surg, Taiyuan, Shanxi, Peoples R China
7.Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjin, Peoples R China
8.Hebei Med Univ, Hosp 4, Breast Ctr, Shijiazhuang, Hebei, Peoples R China
9.Jilin Univ, Hosp 1, Dept Breast Surg, Changchun 130023, Jilin, Peoples R China
10.Chinese Acad Med Sci, Canc Hosp, Dept Breast Surg, Beijing 100730, Peoples R China
11.Peking Univ, Peoples Hosp, Breast Dis Ctr, Beijing 100871, Peoples R China
12.Beijing Chaoyang Hosp, Dept Gen Surg, Beijing, Peoples R China
13.Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin, Heilongjiang, Peoples R China
14.China Med Univ, Affiliated Hosp 1, Dept Breast Surg, Shenyang 110001, Liaoning, Peoples R China
15.Nanjing Med Univ, Affiliated Canc Hosp, Canc Inst Jiangsu Prov, Dept Gen Surg, Nanjing, Jiangsu, Peoples R China
16.Linyi Peoples Hosp, Dept Gen Surg, Linyi, Shandong, Peoples R China
17.Binzhou Med Univ, Affiliated Hosp 1, Dept Thyroid & Breast Surg, Binzhou, Shandong, Peoples R China
18.Qingdao Univ, Affiliated Hosp, Breast Ctr, Qingdao 266071, Shandong, Peoples R China
19.Weifang Tradit Chinese Hosp, Dept Breast & Thyroid Surg, Weifang, Shandong, Peoples R China
20.Zibo Cent Hosp, Dept Breast & Thyroid Surg, Zibo, Shandong, Peoples R China
21.Yantai Yuhuangding Hosp, Dept Breast Surg, Yantai, Shandong, Peoples R China
22.Shandong Canc Hosp, Breast Canc Ctr, Jinan, Shandong, Peoples R China
23.Shandong Univ, Sch Publ Hlth, Inst Epidemiol, Jinan 250100, Shandong, Peoples R China
24.Shandong Univ, Sch Publ Hlth, Div Epidemiol & Biostat, Jinan 250100, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Shi-guang,Guo, Ming-ming,Duan, Xue-ning,et al. Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study[J]. PLOS ONE,2015,10(6).
APA Zhu, Shi-guang.,Guo, Ming-ming.,Duan, Xue-ning.,Cui, Shu-de.,Tian, Fu-guo.,...&Yu, Zhi-gang.(2015).Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study.PLOS ONE,10(6).
MLA Zhu, Shi-guang,et al."Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study".PLOS ONE 10.6(2015).
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