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学科主题: 临床医学
题名:
Secondary Screening After Primary Self-Sampling for Human Papillomavirus From SHENCCAST II
作者: Wu, Ruifang1; Du, Hui1; Belinson, Suzanne Elizabeth1; Pretorius, Robert Gerald2; Zou, Jing3; Yang, Bin4; Wang, Chun1; Belinson, Jerome Leslie5
关键词: screening ; HPV ; self-sampling ; cervical cancer ; secondary screening
刊名: JOURNAL OF LOWER GENITAL TRACT DISEASE
发表日期: 2012-10-01
卷: 16, 期:4, 页:416-420
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: CERVICAL CYTOLOGY ; HPV HR ; WOMEN ; PERFORMANCE ; DETECT ; TRIAL
英文摘要:

Objective. We recently demonstrated that a self-collected sample tested with a high-throughput polymerase chain reaction based high-risk human papillomavirus (HR-HPV) assay is equal in sensitivity to a physician-obtained direct endocervical sample. We now explore some secondary screening options to improve specificity.

Methods. The Shenzhen Cervical Cancer Screening Trial II is a multisite, population-based cross-sectional cervical cancer screening study conducted in Guangdong Province, China. Two HR-HPV assays were used for self-collected specimens, and 3 assays were used for directly collected specimens along with cytology. The polymerase chain reaction based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay reported 14 HR-HPV types. Any patient with a positive lesion on any assay or cytology underwent colposcopy and biopsy.

Results. A total of 8,556 women with a mean age of 38.9 years (range = 25-54 years) were included in the analysis. Primary self-collection had a sensitivity of 94.3% and a specificity of 87.5% (for cervical intraepithelial neoplasia grade 3 or cancer). Secondary cervical cytology had a sensitivity and specificity of 83.0% and 95.2%, respectively, which would require a pelvic examination and sacrifice some sensitivity. Secondary genotyping for HPV types 16 or 18 had a sensitivity and specificity of 53.9% and 97.7%, respectively; and HPV types 16, 18, 31, 33, 45, 52, and 58 had a sensitivity and specificity of 92.2% and 90.4%, respectively.

Conclusions. Genotyping is efficient if it is part of the primary test result. It potentially identifies a high percentage of the cancers (types 16/18 = 84.5% in China).

语种: 英语
WOS记录号: WOS:000309326200015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50184
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China
2.Kaiser Permanente, Fontana, CA USA
3.BGI, Shenzhen, Peoples R China
4.Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA
5.Cleveland Clin, Lerner Coll Med, Womens Hlth Inst, Cleveland, OH 44106 USA

Recommended Citation:
Wu, Ruifang,Du, Hui,Belinson, Suzanne Elizabeth,et al. Secondary Screening After Primary Self-Sampling for Human Papillomavirus From SHENCCAST II[J]. JOURNAL OF LOWER GENITAL TRACT DISEASE,2012,16(4):416-420.
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