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Effects of intermedin(1-53) on cardiac function and ischemia/reperfusion injury in isolated rat hearts
Yang, JH1; Jia, YX1; Pan, CS1; Zhao, J1; Ouyang, M1; Yang, J1; Chang, JK1; Tang, CS1; Qi, YF1
关键词Intermedin Ischemia/reperfusion Camp Heart
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2005-02-18
DOI10.1016/j.bbrc.2004.12.071
327期:3页:713-719
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]GENE-RELATED PEPTIDE ; ACTIVITY-MODIFYING PROTEINS ; ADRENOMEDULLIN ; IDENTIFICATION ; EXPRESSION ; RECEPTORS ; AMYLIN ; FAMILY
英文摘要

Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide (CT/CGRP) family identified from human and other vertebrate tissues. Preprointermedin (preproIMD) can generate a 47 amino acid mature peptide (IMD1-47) and a shorter 40 amino acid one (IMD8-47) by proteolytic cleavage. Amino acid sequence analysis showed that cleavage sites are located between two basic amino acids at Arg93-Arg94, resulting in the production of preproIMD(95-147), namely IMD1-53. The present study was designed to observe the effects of IMD1-53 on cardiac function in ischemia/reperfusion (I/R) injury in isolated rat hearts. Perfusion with high-dose IMD1-53 gave higher left ventricular systolic pressure (LVSP) and maximal rate of increase and decrease of left ventricle pressure ( +/-LVdP/dt(max)), and coronary perfusion flow (CPF) than those of controls. Cardiac I/R induced a marked inhibition of cardiac function and myocardial injury. Reperfusion with IMD1-53 significantly ameliorated the inhibited cardiac function and bradycardia induced by I/R. Compared with the I/R-treatment alone, IMD1-53 reperfusion augmented CPF, LVSP, and maximal rate of increase and decrease of left ventricle pressure (+/-LVdP/dt(max)) and decreased LVDP. In addition, reperfusion with IMD1-53 markedly attenuated the leakage of lactate dehydrogenase and malondialdehyde content in myocardia compared with I/R alone. Reperfusion with IMD(1-53)increased the content of cyclic adenosine monophosphate in comparison with I/R alone. Interestingly, the above IMD1-53 effects are similar to those of adrenomedullin. These results suggest that IMD1-53, like adrenomedullin, has cardioprotective effects against myocardial I/R injury. (C) 2004 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000226674800013
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50194
专题北京大学第一临床医学院_心血管内科
北京大学第二临床医学院_肾内科
作者单位1.Peking Univ, Hosp 1, Cardiovasc Res Inst, Beijing 100034, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
4.Phoenix Pharmaceut Inc, Belmont, CA 94002 USA
推荐引用方式
GB/T 7714
Yang, JH,Jia, YX,Pan, CS,et al. Effects of intermedin(1-53) on cardiac function and ischemia/reperfusion injury in isolated rat hearts[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,327(3):713-719.
APA Yang, JH.,Jia, YX.,Pan, CS.,Zhao, J.,Ouyang, M.,...&Qi, YF.(2005).Effects of intermedin(1-53) on cardiac function and ischemia/reperfusion injury in isolated rat hearts.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,327(3),713-719.
MLA Yang, JH,et al."Effects of intermedin(1-53) on cardiac function and ischemia/reperfusion injury in isolated rat hearts".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327.3(2005):713-719.
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