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学科主题: 临床医学
题名:
Effects of intermedin(1-53) on cardiac function and ischemia/reperfusion injury in isolated rat hearts
作者: Yang, JH1; Jia, YX1; Pan, CS1; Zhao, J1; Ouyang, M1; Yang, J1; Chang, JK1; Tang, CS1; Qi, YF1
关键词: intermedin ; ischemia/reperfusion ; cAMP ; heart
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2005-02-18
DOI: 10.1016/j.bbrc.2004.12.071
卷: 327, 期:3, 页:713-719
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: GENE-RELATED PEPTIDE ; ACTIVITY-MODIFYING PROTEINS ; ADRENOMEDULLIN ; IDENTIFICATION ; EXPRESSION ; RECEPTORS ; AMYLIN ; FAMILY
英文摘要:

Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide (CT/CGRP) family identified from human and other vertebrate tissues. Preprointermedin (preproIMD) can generate a 47 amino acid mature peptide (IMD1-47) and a shorter 40 amino acid one (IMD8-47) by proteolytic cleavage. Amino acid sequence analysis showed that cleavage sites are located between two basic amino acids at Arg93-Arg94, resulting in the production of preproIMD(95-147), namely IMD1-53. The present study was designed to observe the effects of IMD1-53 on cardiac function in ischemia/reperfusion (I/R) injury in isolated rat hearts. Perfusion with high-dose IMD1-53 gave higher left ventricular systolic pressure (LVSP) and maximal rate of increase and decrease of left ventricle pressure ( +/-LVdP/dt(max)), and coronary perfusion flow (CPF) than those of controls. Cardiac I/R induced a marked inhibition of cardiac function and myocardial injury. Reperfusion with IMD1-53 significantly ameliorated the inhibited cardiac function and bradycardia induced by I/R. Compared with the I/R-treatment alone, IMD1-53 reperfusion augmented CPF, LVSP, and maximal rate of increase and decrease of left ventricle pressure (+/-LVdP/dt(max)) and decreased LVDP. In addition, reperfusion with IMD1-53 markedly attenuated the leakage of lactate dehydrogenase and malondialdehyde content in myocardia compared with I/R alone. Reperfusion with IMD(1-53)increased the content of cyclic adenosine monophosphate in comparison with I/R alone. Interestingly, the above IMD1-53 effects are similar to those of adrenomedullin. These results suggest that IMD1-53, like adrenomedullin, has cardioprotective effects against myocardial I/R injury. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000226674800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50194
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Cardiovasc Res Inst, Beijing 100034, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
4.Phoenix Pharmaceut Inc, Belmont, CA 94002 USA

Recommended Citation:
Yang, JH,Jia, YX,Pan, CS,et al. Effects of intermedin(1-53) on cardiac function and ischemia/reperfusion injury in isolated rat hearts[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,327(3):713-719.
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