IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Fetal Human Keratinocytes Produce Large Amounts of Antimicrobial Peptides: Involvement of Histone-Methylation Processes
Gschwandtner, Maria1; Zhong, Shaomin1,2; Tschachler, Antonia1; Mlitz, Veronika1; Karner, Susanne1; Elbe-Buerger, Adelheid3; Mildner, Michael1
刊名JOURNAL OF INVESTIGATIVE DERMATOLOGY
2014-08-01
DOI10.1038/jid.2014.165
134期:8页:2192-2201
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]TOLL-LIKE RECEPTORS ; HUMAN SKIN ; AMNIOTIC-FLUID ; EPIDERMAL-KERATINOCYTES ; MAMMALIAN DEFENSINS ; PROTEIN PSORIASIN ; ESCHERICHIA-COLI ; VERNIX CASEOSA ; IMMUNITY ; ACTIVATION
英文摘要

Antimicrobial peptides (AMPs), an important part of the innate immune system, are crucial for defense against invading microorganisms. Whereas AMPs have been extensively studied in adult skin, little is known about the impact of AMPs in the developing human skin. We therefore compared the expression and regulation of AMPs in fetal, neonatal, and adult keratinocytes (KCs) in vitro. The constitutive expression of human beta-defensin-2 (HBD-2), HBD-3, S100 protein family members, and cathelicidin was significantly higher in KCs from fetal skin than in KCs from postnatal skin. The capacity to further increase AMP production was comparable between prenatal and postnatal KCs. Analysis of skin equivalents (SEs) revealed a strong constitutive expression of S100 proteins in fetal but not in neonatal and adult SEs. The elevated AMP levels correlated with reduced H3K27me3 (tri-methyl-lysine 27 on histone H3) levels and increased expression of the histone demethylase JMJD3. Knockdown of JMJD3 in fetal KCs elevated H3K27me3 levels and significantly downregulated the expression of HBD-3, S100A7, S100A8, S100A9, and cathelicidin. Our data indicate a crucial contribution of histone modifications in the regulation of AMP expression in the skin during ontogeny. The elevated AMP expression in prenatal skin might represent an essential defense strategy of the unborn.

语种英语
WOS记录号WOS:000339126100020
项目编号P19474-813 ; T545-B19
资助机构Austrian Science Fund
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50196
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Med Univ Vienna, Dept Dermatol, Res Div Biol & Pathobiol Skin, A-1090 Vienna, Austria
2.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100871, Peoples R China
3.Med Univ Vienna, Lab Cellular & Mol Immunobiol Skin, Div Immunol Allergy & Infect Dis, Dept Dermatol, A-1090 Vienna, Austria
推荐引用方式
GB/T 7714
Gschwandtner, Maria,Zhong, Shaomin,Tschachler, Antonia,et al. Fetal Human Keratinocytes Produce Large Amounts of Antimicrobial Peptides: Involvement of Histone-Methylation Processes[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY,2014,134(8):2192-2201.
APA Gschwandtner, Maria.,Zhong, Shaomin.,Tschachler, Antonia.,Mlitz, Veronika.,Karner, Susanne.,...&Mildner, Michael.(2014).Fetal Human Keratinocytes Produce Large Amounts of Antimicrobial Peptides: Involvement of Histone-Methylation Processes.JOURNAL OF INVESTIGATIVE DERMATOLOGY,134(8),2192-2201.
MLA Gschwandtner, Maria,et al."Fetal Human Keratinocytes Produce Large Amounts of Antimicrobial Peptides: Involvement of Histone-Methylation Processes".JOURNAL OF INVESTIGATIVE DERMATOLOGY 134.8(2014):2192-2201.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Gschwandtner, Maria]的文章
[Zhong, Shaomin]的文章
[Tschachler, Antonia]的文章
百度学术
百度学术中相似的文章
[Gschwandtner, Maria]的文章
[Zhong, Shaomin]的文章
[Tschachler, Antonia]的文章
必应学术
必应学术中相似的文章
[Gschwandtner, Maria]的文章
[Zhong, Shaomin]的文章
[Tschachler, Antonia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。