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学科主题: 基础医学
题名:
TFAR19 enhances the opening of permeability transition pore in the mitochondrial membrane of mice liver
作者: Tian, HK1; Xia, T1; Jiang, CS1; Zhang, HM1; Wang, K1; Li, XJ1
关键词: apoptosis ; TFAR19 ; mitochondria ; PTP ; membrane potential
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
发表日期: 2002-05-01
卷: 34, 期:3, 页:279-284
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CELL-DEATH ; APOPTOSIS ; BCL-2 ; GENE
英文摘要:

TFAR19(TF-1 cell apoptosis related gene 19) is a novel apoptosis-related gene cloned from human leukemia cell line TF-1 cells undergoing apoptosis in 1999 (accession number AF014955 in GenBank). The human TFAR19 encodes a protein which shares significant homology to the corresponding proteins of species ranging from yeast to mice. TFAR 19 exhibits a ubiquitous expression pattern and its expression is upregulated in tumor cells undergoing apoptosis. Overexpression of TFAR 19 could enhance apoptosis of some tumor cells induced by growth factor withdrawal or serum deprivation. But the exact mechanism of TFAR 19 is unclear. Mitochondria not only provides energy for the cell, but also plays a critical rate on cell death or survival. The release of apoptosis promoting factor, such as cytochrome c from mitochondria, resulted by the damage of mitochondrial membrane integrity, is the key factor controlling apoptosis. The permeability transition pore (FIT) of mitochondria is a protein complex located between the mitochondrial membranes, and it plays an important role in regulating the integrity of mitochondrial membrane. In this study, the effect of recombinant TFAR 19 an isolated mitochondrial PTP, membrane potential, and release of cytochrome c was investigated in vitro. The results indicated that recombinant TFAR 19 facilitated the isolated mitochondrial PTP opening, decreased the membrane potential, and promoted the release of cytochrome c. The effect of TFAR 19 on mitochondria is implemented by opening the mitochondrial PTP. Experimental results implicate that TFAR 19 may positively feedback apoptosis signal of mitochondria, forming a positive loop to promote apoptosis.

语种: 中文
WOS记录号: WOS:000175697900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50203
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Natl Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
3.Tianjin Sports Inst, Tianjin 300381, Peoples R China
4.Peking Univ, Affiliated Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Tian, HK,Xia, T,Jiang, CS,et al. TFAR19 enhances the opening of permeability transition pore in the mitochondrial membrane of mice liver[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2002,34(3):279-284.
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