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学科主题基础医学
TFAR19 enhances the opening of permeability transition pore in the mitochondrial membrane of mice liver
Tian, HK1; Xia, T1; Jiang, CS1; Zhang, HM1; Wang, K1; Li, XJ1
关键词Apoptosis Tfar19 Mitochondria Ptp Membrane Potential
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
2002-05-01
34期:3页:279-284
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CELL-DEATH ; APOPTOSIS ; BCL-2 ; GENE
英文摘要

TFAR19(TF-1 cell apoptosis related gene 19) is a novel apoptosis-related gene cloned from human leukemia cell line TF-1 cells undergoing apoptosis in 1999 (accession number AF014955 in GenBank). The human TFAR19 encodes a protein which shares significant homology to the corresponding proteins of species ranging from yeast to mice. TFAR 19 exhibits a ubiquitous expression pattern and its expression is upregulated in tumor cells undergoing apoptosis. Overexpression of TFAR 19 could enhance apoptosis of some tumor cells induced by growth factor withdrawal or serum deprivation. But the exact mechanism of TFAR 19 is unclear. Mitochondria not only provides energy for the cell, but also plays a critical rate on cell death or survival. The release of apoptosis promoting factor, such as cytochrome c from mitochondria, resulted by the damage of mitochondrial membrane integrity, is the key factor controlling apoptosis. The permeability transition pore (FIT) of mitochondria is a protein complex located between the mitochondrial membranes, and it plays an important role in regulating the integrity of mitochondrial membrane. In this study, the effect of recombinant TFAR 19 an isolated mitochondrial PTP, membrane potential, and release of cytochrome c was investigated in vitro. The results indicated that recombinant TFAR 19 facilitated the isolated mitochondrial PTP opening, decreased the membrane potential, and promoted the release of cytochrome c. The effect of TFAR 19 on mitochondria is implemented by opening the mitochondrial PTP. Experimental results implicate that TFAR 19 may positively feedback apoptosis signal of mitochondria, forming a positive loop to promote apoptosis.

语种中文
WOS记录号WOS:000175697900004
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50203
专题北京大学基础医学院_药理学系
北京大学基础医学院
北京大学药学院
北京大学药学院_化学生物学系
北京大学第三临床医学院_骨科
北京大学第三临床医学院_医学工程处
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Natl Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
3.Tianjin Sports Inst, Tianjin 300381, Peoples R China
4.Peking Univ, Affiliated Hosp 3, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Tian, HK,Xia, T,Jiang, CS,et al. TFAR19 enhances the opening of permeability transition pore in the mitochondrial membrane of mice liver[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2002,34(3):279-284.
APA Tian, HK,Xia, T,Jiang, CS,Zhang, HM,Wang, K,&Li, XJ.(2002).TFAR19 enhances the opening of permeability transition pore in the mitochondrial membrane of mice liver.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,34(3),279-284.
MLA Tian, HK,et al."TFAR19 enhances the opening of permeability transition pore in the mitochondrial membrane of mice liver".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 34.3(2002):279-284.
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