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学科主题: 药学
题名:
Anti hypertensive effect of 3,3,5,5-tetramethyl-4-piperidone, a new compound extracted from Marasmius androsaceus
作者: Zhang, Ling1,2; Yang, Ming3; Song, Yan4; Sun, Zhongwei5; Peng, Yi5; Qu, Kai1,2; Zhu, Haibo1,2
关键词: 3,3,5,5-Tetramethyl-4-piperidone ; Hypertension ; Ganglionic blocking
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2009-05-04
DOI: 10.1016/j.jep.2009.02.033
卷: 123, 期:1, 页:34-39
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: MEDICINAL MUSHROOM ; HEART-RATE ; MANAGEMENT ; PRESSURE ; FAILURE ; MYCELIA ; CHINA
英文摘要:

Aim of the study: To evaluate the antihypertensive effect of 3,3,5,5-tetramethyl-4-piperidone (TMP), a new compound extracted from Marasmius androsaceus. Besides, the hemodynamic profiles and pertinent mechanism of the compound were explored.

Materials and methods: Acute and chronic antihypertensive effects of TMP were examined in spontaneous hypertensive rats (SHRs) and reno-hypertensive rats (two kidneys one clip model, 2K1C). Anesthetized dogs were used to evaluate the hemodynamic effects of TMP. Moreover, the cat nictitating membrane response was used to test the ganglionic blocking property of TMP.

Results: TMP (2.5, 5 and 10 mg/kg, p.o.) notably reduced the blood pressure of SHR in 30 min. Two-week administration of TMP (2.5, 5 and 10 mg/kg, p.o.) also decreased the blood pressure of 2K1C rats. TMP (30 mg/kg, i.v.) abolished the response of the nictitating membrane induced by preganglionic stimulation. The results of hemodynamic study in anesthetized dogs showed that, except for the reduction in blood pressure and left ventricular work, no other changes were detected. The results of heart rate variability analysis indicated an intact sympathetic-vagal balance after TMP treatment.

Conclusions: TMP is a new anti hypertensive compound, and the effect is partially related to ganglionic blocking. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30873063 ; zhuhaibo-504 3&prime ; -deoxyadenosine ; 2004CB518906 ; IRT0514
项目资助者: Natural Sciences Foundation of China (NSFC) ; Chinese Academy of Medical Sciences ; National 973 Fundamental Project of China ; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)
WOS记录号: WOS:000266124600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50212
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Mat Med, Minist Educ, Key Lab Bioact Substances & Resources Utilizat Ch, Beijing 100050, Peoples R China
2.Peking Union Med Coll, Beijing 100050, Peoples R China
3.Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
5.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China

Recommended Citation:
Zhang, Ling,Yang, Ming,Song, Yan,et al. Anti hypertensive effect of 3,3,5,5-tetramethyl-4-piperidone, a new compound extracted from Marasmius androsaceus[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,123(1):34-39.
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