IR@PKUHSC  > 北京大学药学院
学科主题药学
Anti hypertensive effect of 3,3,5,5-tetramethyl-4-piperidone, a new compound extracted from Marasmius androsaceus
Zhang, Ling1,2; Yang, Ming3; Song, Yan4; Sun, Zhongwei5; Peng, Yi5; Qu, Kai1,2; Zhu, Haibo1,2
关键词Hypertension 3 Ganglionic Blocking 3 5 5-tetramethyl-4-piperidone
刊名JOURNAL OF ETHNOPHARMACOLOGY
2009-05-04
DOI10.1016/j.jep.2009.02.033
123期:1页:34-39
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]MEDICINAL MUSHROOM ; HEART-RATE ; MANAGEMENT ; PRESSURE ; FAILURE ; MYCELIA ; CHINA
英文摘要

Aim of the study: To evaluate the antihypertensive effect of 3,3,5,5-tetramethyl-4-piperidone (TMP), a new compound extracted from Marasmius androsaceus. Besides, the hemodynamic profiles and pertinent mechanism of the compound were explored.

Materials and methods: Acute and chronic antihypertensive effects of TMP were examined in spontaneous hypertensive rats (SHRs) and reno-hypertensive rats (two kidneys one clip model, 2K1C). Anesthetized dogs were used to evaluate the hemodynamic effects of TMP. Moreover, the cat nictitating membrane response was used to test the ganglionic blocking property of TMP.

Results: TMP (2.5, 5 and 10 mg/kg, p.o.) notably reduced the blood pressure of SHR in 30 min. Two-week administration of TMP (2.5, 5 and 10 mg/kg, p.o.) also decreased the blood pressure of 2K1C rats. TMP (30 mg/kg, i.v.) abolished the response of the nictitating membrane induced by preganglionic stimulation. The results of hemodynamic study in anesthetized dogs showed that, except for the reduction in blood pressure and left ventricular work, no other changes were detected. The results of heart rate variability analysis indicated an intact sympathetic-vagal balance after TMP treatment.

Conclusions: TMP is a new anti hypertensive compound, and the effect is partially related to ganglionic blocking. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000266124600006
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50212
Collection北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Chinese Acad Med Sci, Inst Mat Med, Minist Educ, Key Lab Bioact Substances & Resources Utilizat Ch, Beijing 100050, Peoples R China
2.Peking Union Med Coll, Beijing 100050, Peoples R China
3.Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
5.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ling,Yang, Ming,Song, Yan,et al. Anti hypertensive effect of 3,3,5,5-tetramethyl-4-piperidone, a new compound extracted from Marasmius androsaceus[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,123(1):34-39.
APA Zhang, Ling.,Yang, Ming.,Song, Yan.,Sun, Zhongwei.,Peng, Yi.,...&Zhu, Haibo.(2009).Anti hypertensive effect of 3,3,5,5-tetramethyl-4-piperidone, a new compound extracted from Marasmius androsaceus.JOURNAL OF ETHNOPHARMACOLOGY,123(1),34-39.
MLA Zhang, Ling,et al."Anti hypertensive effect of 3,3,5,5-tetramethyl-4-piperidone, a new compound extracted from Marasmius androsaceus".JOURNAL OF ETHNOPHARMACOLOGY 123.1(2009):34-39.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Zhang, Ling]'s Articles
[Yang, Ming]'s Articles
[Song, Yan]'s Articles
百度学术
百度学术Similar articles in
[Zhang, Ling]'s Articles
[Yang, Ming]'s Articles
[Song, Yan]'s Articles
必应学术
必应学术Similar articles in
[Zhang, Ling]'s Articles
[Yang, Ming]'s Articles
[Song, Yan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.