IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure
Yang, Sheng-Tao1,2; Wang, Tiancheng3; Dong, Erya2; Chen, Xin-Xin2; Xiang, Kun2; Liu, Jia-Hui2,4; Liu, Yuanfang2,4; Wang, Haifang2
刊名TOXICOLOGY RESEARCH
2012
DOI10.1039/c2tx20008b
1期:1页:69-74
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
资助者China Ministry of Science and Technology ; China Natural Science Foundation ; Key Project of Chinese Ministry of Education ; Fundamental Research Funds for the Central Universities, Southwest University for Nationalities ; China Ministry of Science and Technology ; China Natural Science Foundation ; Key Project of Chinese Ministry of Education ; Fundamental Research Funds for the Central Universities, Southwest University for Nationalities
研究领域[WOS]Toxicology
关键词[WOS]WALLED CARBON NANOTUBES ; CAENORHABDITIS-ELEGANS ; COPPER NANOPARTICLES ; OXIDE ; PARTICLES ; ZINC ; MICE ; BIODISTRIBUTION ; TRANSLOCATION ; CYTOTOXICITY
英文摘要

Alumina nanoparticles (NPs) are among the most important nanomaterials and are widely used in diverse areas. In this study, we evaluated the bioavailability and toxicity of alumina NPs in mice after oral exposure, compared with traditional alumina powder. Our results indicated that negligible alumina NPs were absorbed post-exposure and alumina NPs did not influence the balance of essential trace elements, including Fe, Cu and Zn. Preliminary toxicological evaluations suggested that alumina NPs were of low toxicity. The body weights were similar among the mice exposed to alumina NPs, alumina powder and 0.9% NaCl aqueous solution. The low toxicity was also indicated by the unchanged serum biochemical parameters. The implications related to the ongoing safety evaluations and applications of alumina NPs are discussed.

语种英语
所属项目编号2011CB933402 ; 21071094 ; 211053 ; 11NZYBS06
资助者China Ministry of Science and Technology ; China Natural Science Foundation ; Key Project of Chinese Ministry of Education ; Fundamental Research Funds for the Central Universities, Southwest University for Nationalities ; China Ministry of Science and Technology ; China Natural Science Foundation ; Key Project of Chinese Ministry of Education ; Fundamental Research Funds for the Central Universities, Southwest University for Nationalities
WOS记录号WOS:000315731500009
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50215
专题北京大学第三临床医学院
作者单位1.Southwest Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100083, Peoples R China
4.Peking Univ, Beijing Natl Lab Mol Sci, Dept Biol Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, Sheng-Tao,Wang, Tiancheng,Dong, Erya,et al. Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure[J]. TOXICOLOGY RESEARCH,2012,1(1):69-74.
APA Yang, Sheng-Tao.,Wang, Tiancheng.,Dong, Erya.,Chen, Xin-Xin.,Xiang, Kun.,...&Wang, Haifang.(2012).Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure.TOXICOLOGY RESEARCH,1(1),69-74.
MLA Yang, Sheng-Tao,et al."Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure".TOXICOLOGY RESEARCH 1.1(2012):69-74.
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