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学科主题: 临床医学
题名:
Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure
作者: Yang, Sheng-Tao1,2; Wang, Tiancheng3; Dong, Erya2; Chen, Xin-Xin2; Xiang, Kun2; Liu, Jia-Hui2,4; Liu, Yuanfang2,4; Wang, Haifang2
刊名: TOXICOLOGY RESEARCH
发表日期: 2012
DOI: 10.1039/c2tx20008b
卷: 1, 期:1, 页:69-74
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: WALLED CARBON NANOTUBES ; CAENORHABDITIS-ELEGANS ; COPPER NANOPARTICLES ; OXIDE ; PARTICLES ; ZINC ; MICE ; BIODISTRIBUTION ; TRANSLOCATION ; CYTOTOXICITY
英文摘要:

Alumina nanoparticles (NPs) are among the most important nanomaterials and are widely used in diverse areas. In this study, we evaluated the bioavailability and toxicity of alumina NPs in mice after oral exposure, compared with traditional alumina powder. Our results indicated that negligible alumina NPs were absorbed post-exposure and alumina NPs did not influence the balance of essential trace elements, including Fe, Cu and Zn. Preliminary toxicological evaluations suggested that alumina NPs were of low toxicity. The body weights were similar among the mice exposed to alumina NPs, alumina powder and 0.9% NaCl aqueous solution. The low toxicity was also indicated by the unchanged serum biochemical parameters. The implications related to the ongoing safety evaluations and applications of alumina NPs are discussed.

语种: 英语
所属项目编号: 2011CB933402 ; 21071094 ; 211053 ; 11NZYBS06
项目资助者: China Ministry of Science and Technology ; China Natural Science Foundation ; Key Project of Chinese Ministry of Education ; Fundamental Research Funds for the Central Universities, Southwest University for Nationalities
WOS记录号: WOS:000315731500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50215
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Southwest Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100083, Peoples R China
4.Peking Univ, Beijing Natl Lab Mol Sci, Dept Biol Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Sheng-Tao,Wang, Tiancheng,Dong, Erya,et al. Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure[J]. TOXICOLOGY RESEARCH,2012,1(1):69-74.
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