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学科主题临床医学
Catestatin could ameliorate proliferating changes of target organs in spontaneously hypertensive rats
Liu Ran; Sun Ning-ling; Yang Song-na; Guo Jian-qiang
关键词Catestatin Spontaneously Hypertensive Rat Target-organ Structure Interstitial Collagen
刊名CHINESE MEDICAL JOURNAL
2013-06-05
DOI10.3760/cma.j.issn.0366-6999.20120757
126期:11页:2157-2162
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INHIBITORY PEPTIDE CATESTATIN ; CHROMOGRANIN-A FRAGMENT ; CATECHOLAMINE RELEASE ; IN-VIVO ; A(344-364) ; EXPRESSION ; HISTAMINE ; MIGRATION ; HUMANS ; CELLS
英文摘要

Background Catestatin, a chromogranin A-derived peptide, is a potent antagonist of nicotine-evoked catecholamine release. We know that catecholamine plays an important role in cardiovascular remodeling induced by hypertension, therefore we hypothesized that catestatin would affect target-organ structure during hypertension.

Methods Twelve spontaneously hypertensive rats (SHRs) were randomized to SHR control group and catestatin group, the normal control group was comprised of six healthy Wistar-Kyoto rats of the same age. Tail-cuff blood pressure and pulse rate were obtained at weeks 1, 4 and 8. At the end of the eight-week period, the heart, abdominal aorta and left kidney were excised and weighed, VG staining was done and the intima-media thickness of vessels and the collagen volume fraction were assessed by an image acquisition and analysis system. The proliferating cell nuclear antigen (PCNA) was observed by immunohistochemistry, and real time reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the nnRNA levels of proliferative genes including cyclin A, ki67 and PCNA in the abdominal aorta.

Results All the parameters in SHR observed in the present study increased significantly compared to Wistar Kyoto rats (P <0.01). With intervention with catestatin, the systolic blood pressure decreased slightly but it was not significantly different from the SHR control, the cardiac mass index and left ventricular mass index both decreased significantly, the collagen volume fraction decreased by nearly 30% in the heart, by 25% in vessels and by 10% in the kidney, and the intima-media thickness and expression of proliferative genes, including cyclin A, ki67 and PCNA, in the abdominal aorta also decreased significantly.

Conclusions The present study indicated that catestatin could ameliorate proliferating changes of heart, kidney and vessels during hypertension, especially to the deposition of interstitial collagen. Blood pressure was not the main factor to mediate this effect, which suggested that catestatin could become a novel protective factor for hypertensive target organs.

语种英语
WOS记录号WOS:000321473700030
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50218
专题北京大学第二临床医学院_心血管内科
作者单位Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
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GB/T 7714
Liu Ran,Sun Ning-ling,Yang Song-na,et al. Catestatin could ameliorate proliferating changes of target organs in spontaneously hypertensive rats[J]. CHINESE MEDICAL JOURNAL,2013,126(11):2157-2162.
APA Liu Ran,Sun Ning-ling,Yang Song-na,&Guo Jian-qiang.(2013).Catestatin could ameliorate proliferating changes of target organs in spontaneously hypertensive rats.CHINESE MEDICAL JOURNAL,126(11),2157-2162.
MLA Liu Ran,et al."Catestatin could ameliorate proliferating changes of target organs in spontaneously hypertensive rats".CHINESE MEDICAL JOURNAL 126.11(2013):2157-2162.
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