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学科主题: 临床医学
题名:
Catestatin could ameliorate proliferating changes of target organs in spontaneously hypertensive rats
作者: Liu Ran; Sun Ning-ling; Yang Song-na; Guo Jian-qiang
关键词: catestatin ; spontaneously hypertensive rat ; target-organ structure ; interstitial collagen
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-06-05
DOI: 10.3760/cma.j.issn.0366-6999.20120757
卷: 126, 期:11, 页:2157-2162
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INHIBITORY PEPTIDE CATESTATIN ; CHROMOGRANIN-A FRAGMENT ; CATECHOLAMINE RELEASE ; IN-VIVO ; A(344-364) ; EXPRESSION ; HISTAMINE ; MIGRATION ; HUMANS ; CELLS
英文摘要:

Background Catestatin, a chromogranin A-derived peptide, is a potent antagonist of nicotine-evoked catecholamine release. We know that catecholamine plays an important role in cardiovascular remodeling induced by hypertension, therefore we hypothesized that catestatin would affect target-organ structure during hypertension.

Methods Twelve spontaneously hypertensive rats (SHRs) were randomized to SHR control group and catestatin group, the normal control group was comprised of six healthy Wistar-Kyoto rats of the same age. Tail-cuff blood pressure and pulse rate were obtained at weeks 1, 4 and 8. At the end of the eight-week period, the heart, abdominal aorta and left kidney were excised and weighed, VG staining was done and the intima-media thickness of vessels and the collagen volume fraction were assessed by an image acquisition and analysis system. The proliferating cell nuclear antigen (PCNA) was observed by immunohistochemistry, and real time reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the nnRNA levels of proliferative genes including cyclin A, ki67 and PCNA in the abdominal aorta.

Results All the parameters in SHR observed in the present study increased significantly compared to Wistar Kyoto rats (P <0.01). With intervention with catestatin, the systolic blood pressure decreased slightly but it was not significantly different from the SHR control, the cardiac mass index and left ventricular mass index both decreased significantly, the collagen volume fraction decreased by nearly 30% in the heart, by 25% in vessels and by 10% in the kidney, and the intima-media thickness and expression of proliferative genes, including cyclin A, ki67 and PCNA, in the abdominal aorta also decreased significantly.

Conclusions The present study indicated that catestatin could ameliorate proliferating changes of heart, kidney and vessels during hypertension, especially to the deposition of interstitial collagen. Blood pressure was not the main factor to mediate this effect, which suggested that catestatin could become a novel protective factor for hypertensive target organs.

语种: 英语
WOS记录号: WOS:000321473700030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50218
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Liu Ran,Sun Ning-ling,Yang Song-na,et al. Catestatin could ameliorate proliferating changes of target organs in spontaneously hypertensive rats[J]. CHINESE MEDICAL JOURNAL,2013,126(11):2157-2162.
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