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学科主题: 口腔医学
题名:
Minimally traumatic alveolar ridge augmentation with a tunnel injectable thermo-sensitive alginate scaffold
作者: Li, Yifen1,2; Fang, Xiaoqian1,2; Jiang, Ting1,2
关键词: Alveolar ridge augmentation ; Minimally invasive surgical procedures ; Hydrogel ; Tissue engineering
刊名: JOURNAL OF APPLIED ORAL SCIENCE
发表日期: 2015-03-01
DOI: 10.1590/1678-775720140348
卷: 23, 期:2, 页:215-223
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: NONRESORBABLE HYDROXYLAPATITE ; BONE-FORMATION ; MINERALIZATION ; SUBSTITUTES ; RESORPTION ; PROTEIN-2 ; HYDROGEL ; DELIVERY ; DEFECTS ; REPAIR
英文摘要:

Injectable bone substitutes and techniques have been developed for use in minimally invasive procedures for bone augmentation. Objective: To develop a novel injectable thermo-sensitive alginate hydrogel (TSAH) as a scaffold to induce bone regeneration, using a minimally invasive tunnelling technique. Material and Methods: An injectable TSAH was prepared from a copolymer solution of 8.0 wt% Poly(N-isopropylacrylamide) (PNIPAAm) and 8.0 wt% AAlg-g-PNIPAAm. In vitro properties of the material, such as its microstructure and the sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2), were investigated. Then, with the subperiosteal tunnelling technique, this material, carrying rhBMP-2, was injected under the labial periosteum of the maxillary anterior alveolar ridge in a rabbit model. New bone formation was evaluated by means of X-ray, micro-computed tomography (micro-CT), fluorescence labelling, histological study, and immunohistochemistry study. Results: The material exhibited good injectability and thermo-irreversible properties. SEM showed an interconnected porous microstructure of the TSAH. The result of ALP activity indicated sustained delivery of BMP-2 from the TSAH from days 3 to 15. In a rabbit model, both TSAH and TSAH/rhBMP-2 induced alveolar ridge augmentation. The percentage of mineralised tissue in the TSAH/rhBMP-2 group (41.6 +/- 3.79%) was significantly higher than in the TSAH group (31.3 +/- 7.21%; p < 0.05). The density of the regenerating tissue was higher in the TSAH/rhBMP-2 group than in the other groups (TSAH group, positive control, blank control; p < 0.05). Conclusions: The TSAH provided convenient handling properties for clinical application. To some extent, TSAH could induce ridge augmentation and mineral deposition, which can be enhanced when combined with rhBMP-2 for a minimally invasive tunnelling injection.

语种: 英语
WOS记录号: WOS:000355132300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50222
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
2.Jiangmen Municipal Stomatol Hosp, Dept Prosthodont, Jiangmen, Guangdong, Peoples R China

Recommended Citation:
Li, Yifen,Fang, Xiaoqian,Jiang, Ting. Minimally traumatic alveolar ridge augmentation with a tunnel injectable thermo-sensitive alginate scaffold[J]. JOURNAL OF APPLIED ORAL SCIENCE,2015,23(2):215-223.
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