IR@PKUHSC  > 北京大学口腔医学院  > 口腔修复科
学科主题口腔医学
Minimally traumatic alveolar ridge augmentation with a tunnel injectable thermo-sensitive alginate scaffold
Li, Yifen1,2; Fang, Xiaoqian1,2; Jiang, Ting1,2
关键词Alveolar Ridge Augmentation Minimally Invasive Surgical Procedures Hydrogel Tissue Engineering
刊名JOURNAL OF APPLIED ORAL SCIENCE
2015-03-01
DOI10.1590/1678-775720140348
23期:2页:215-223
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]NONRESORBABLE HYDROXYLAPATITE ; BONE-FORMATION ; MINERALIZATION ; SUBSTITUTES ; RESORPTION ; PROTEIN-2 ; HYDROGEL ; DELIVERY ; DEFECTS ; REPAIR
英文摘要

Injectable bone substitutes and techniques have been developed for use in minimally invasive procedures for bone augmentation. Objective: To develop a novel injectable thermo-sensitive alginate hydrogel (TSAH) as a scaffold to induce bone regeneration, using a minimally invasive tunnelling technique. Material and Methods: An injectable TSAH was prepared from a copolymer solution of 8.0 wt% Poly(N-isopropylacrylamide) (PNIPAAm) and 8.0 wt% AAlg-g-PNIPAAm. In vitro properties of the material, such as its microstructure and the sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2), were investigated. Then, with the subperiosteal tunnelling technique, this material, carrying rhBMP-2, was injected under the labial periosteum of the maxillary anterior alveolar ridge in a rabbit model. New bone formation was evaluated by means of X-ray, micro-computed tomography (micro-CT), fluorescence labelling, histological study, and immunohistochemistry study. Results: The material exhibited good injectability and thermo-irreversible properties. SEM showed an interconnected porous microstructure of the TSAH. The result of ALP activity indicated sustained delivery of BMP-2 from the TSAH from days 3 to 15. In a rabbit model, both TSAH and TSAH/rhBMP-2 induced alveolar ridge augmentation. The percentage of mineralised tissue in the TSAH/rhBMP-2 group (41.6 +/- 3.79%) was significantly higher than in the TSAH group (31.3 +/- 7.21%; p < 0.05). The density of the regenerating tissue was higher in the TSAH/rhBMP-2 group than in the other groups (TSAH group, positive control, blank control; p < 0.05). Conclusions: The TSAH provided convenient handling properties for clinical application. To some extent, TSAH could induce ridge augmentation and mineral deposition, which can be enhanced when combined with rhBMP-2 for a minimally invasive tunnelling injection.

语种英语
WOS记录号WOS:000355132300015
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50222
专题北京大学口腔医学院_口腔修复科
北京大学口腔医学院_第五门诊部
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
2.Jiangmen Municipal Stomatol Hosp, Dept Prosthodont, Jiangmen, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Li, Yifen,Fang, Xiaoqian,Jiang, Ting. Minimally traumatic alveolar ridge augmentation with a tunnel injectable thermo-sensitive alginate scaffold[J]. JOURNAL OF APPLIED ORAL SCIENCE,2015,23(2):215-223.
APA Li, Yifen,Fang, Xiaoqian,&Jiang, Ting.(2015).Minimally traumatic alveolar ridge augmentation with a tunnel injectable thermo-sensitive alginate scaffold.JOURNAL OF APPLIED ORAL SCIENCE,23(2),215-223.
MLA Li, Yifen,et al."Minimally traumatic alveolar ridge augmentation with a tunnel injectable thermo-sensitive alginate scaffold".JOURNAL OF APPLIED ORAL SCIENCE 23.2(2015):215-223.
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