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学科主题基础医学
CAM5.2-positive subserosal myofibroblasts in appendicitis
Hamauzu, Tadashi1; Kuroda, Naoto1; Guo, Limei1; Miyazaki, Eriko1; Hayashi, Yoshihiro1; Toi, Makoto1; Hiroi, Makoto1; Enzan, Hideaki1
关键词appendicitis perforation myofibroblasts
刊名MEDICAL MOLECULAR MORPHOLOGY
2006-12-01
DOI10.1007/s00795-006-0332-9
39期:4页:209-213
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology ; Microscopy ; Pathology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics ; Microscopy ; Pathology
关键词[WOS]CD34-POSITIVE STROMAL CELLS ; SMOOTH-MUSCLE ; H-CALDESMON ; SEROSAL TISSUE ; TUMOR BORDER ; EXPRESSION ; LESIONS
英文摘要

In this study, we examined the distribution and origin of myofibroblasts around the perforations of appendicitis. Stromal cells of 45 cases were studied by immunohistochemistry. In the normal appendix, myofibroblasts were restricted to the mucosa. and CD34-positive stromal cells were distributed in the submucosal and subserosal layers. Some mesothelial cells were positive for cytokeratin CAM5.2, cytokeratin 5, or mesothelial cells (HBME-1). In perforation of appendicitis with both abscess and granulation tissue, a small to moderate or a moderate to large number of myofibroblasts appeared in the subscrosal area around the perforation, respectively, but CD34-positive stromal cells were completely absent there. In the subserosal area of the perforation of appendicitis with abscess, cytokeratin 5-positive stromal cells were absent. However, a small to moderate number of cytokeratin CAM5.2-positive stromal cells were observed there. Double immunostaining showed the coexpression of alpha-smooth muscle actin (ASMA) and cytokeratin CAM5.2 and the coexpression of cytokeratin 5 and cytokeratin CAM5.2 in many or some stellate-shaped or spindle-shaped stromal cells existing in the subserosal area with granulation tissue around the perforation of appendicitis, respectively. Finally, many myofibroblasts appearing in the subserosal area of the perforation of appendicitis may be derived from submesothelial cells or mesothelial cells.

语种英语
WOS记录号WOS:000243137300008
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50225
专题基础医学院_病理学系
作者单位1.Kochi Red Cross Hosp, Dept Pathol & Lab Med, Kochi, Kochi 7808562, Japan
2.Kochi Univ, Kochi Med Sch, Dept Pathol, Program Bioregulat & Genet, Kochi 780, Japan
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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GB/T 7714
Hamauzu, Tadashi,Kuroda, Naoto,Guo, Limei,et al. CAM5.2-positive subserosal myofibroblasts in appendicitis[J]. MEDICAL MOLECULAR MORPHOLOGY,2006,39(4):209-213.
APA Hamauzu, Tadashi.,Kuroda, Naoto.,Guo, Limei.,Miyazaki, Eriko.,Hayashi, Yoshihiro.,...&Enzan, Hideaki.(2006).CAM5.2-positive subserosal myofibroblasts in appendicitis.MEDICAL MOLECULAR MORPHOLOGY,39(4),209-213.
MLA Hamauzu, Tadashi,et al."CAM5.2-positive subserosal myofibroblasts in appendicitis".MEDICAL MOLECULAR MORPHOLOGY 39.4(2006):209-213.
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