北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 生物化学与分子生物学系  > 期刊论文
学科主题: 基础医学
题名:
Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration
作者: Wei, Wei1,2; Wang, Lian-Yan1; Yuan, Lan3; Yang, Xiao-Da3; Su, Zhi-Guo1; Ma, Guang-Hui1
关键词: chitosan ; microsphere ; bioadhesion ; absorption ; distribution ; biodegradation
刊名: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
发表日期: 2008-08-01
DOI: 10.1016/j.ejpb.2008.02.011
卷: 69, 期:3, 页:878-886
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DELIVERY SYSTEMS ; NANOPARTICLES ; NANOSPHERES ; HEMOGLOBIN ; PROTEINS ; CAPACITY ; RELEASE ; DRUG
英文摘要:

Chitosan microspheres have a great potential in pharmaceutical application. In this study, uniform-sized chitosan microspheres crosslinked with glutaraldehyde (CG microspheres) were prepared by Shirasu Porous Glass (SPG) membrane emulsification technique. Based on the characterizations of uniform size and autofluorescence, it was possible to develop a new detecting system for observing and quantifying the CG microspheres in rats with three different diameters (2.1. 7.2 and 12.5 mu m) synchronously after oral administration. This system was a combination of scanning electron microscopy (SEM), laser scanning confocal microscope (LSCM) and flow cytometer technique. which showed the advantages of being simple, intuitionistic. repeatable and sensitive. After oral administration of three kinds of particles with different diameters. bioadhesion in gastrointestinal tract, absorption in gastrointestinal tract, distribution in systemic tissues, and biodegradation in reticuloendothelial system (RES) were studied firstly in detail. The CG microspheres showed different fates in bioadhesion, absorption and distribution according to their diameters, while the biodegradation also varied due to the different locations in RES. These original results would indicate a better way for the CG microspheres in the clinical application. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 20536050 ; 20221603 ; 20636010 ; KJCX2-YW-M02 ; 2007AA09Z439
项目资助者: National Nature Science Foundation of China ; Chinese Academy of Sciences ; 863 HighTech program
WOS记录号: WOS:000258882200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50226
Appears in Collections:基础医学院_生物化学与分子生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100080, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Beijing 100871, Peoples R China

Recommended Citation:
Wei, Wei,Wang, Lian-Yan,Yuan, Lan,et al. Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2008,69(3):878-886.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wei, Wei]'s Articles
[Wang, Lian-Yan]'s Articles
[Yuan, Lan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wei, Wei]‘s Articles
[Wang, Lian-Yan]‘s Articles
[Yuan, Lan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace