IR@PKUHSC  > 北京大学基础医学院  > 生物化学与分子生物学系
学科主题基础医学
Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration
Wei, Wei1,2; Wang, Lian-Yan1; Yuan, Lan3; Yang, Xiao-Da3; Su, Zhi-Guo1; Ma, Guang-Hui1
关键词Chitosan Microsphere Bioadhesion Absorption Distribution Biodegradation
刊名EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2008-08-01
DOI10.1016/j.ejpb.2008.02.011
69期:3页:878-886
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Nature Science Foundation of China ; Chinese Academy of Sciences ; 863 HighTech program ; National Nature Science Foundation of China ; Chinese Academy of Sciences ; 863 HighTech program
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]DELIVERY SYSTEMS ; NANOPARTICLES ; NANOSPHERES ; HEMOGLOBIN ; PROTEINS ; CAPACITY ; RELEASE ; DRUG
英文摘要

Chitosan microspheres have a great potential in pharmaceutical application. In this study, uniform-sized chitosan microspheres crosslinked with glutaraldehyde (CG microspheres) were prepared by Shirasu Porous Glass (SPG) membrane emulsification technique. Based on the characterizations of uniform size and autofluorescence, it was possible to develop a new detecting system for observing and quantifying the CG microspheres in rats with three different diameters (2.1. 7.2 and 12.5 mu m) synchronously after oral administration. This system was a combination of scanning electron microscopy (SEM), laser scanning confocal microscope (LSCM) and flow cytometer technique. which showed the advantages of being simple, intuitionistic. repeatable and sensitive. After oral administration of three kinds of particles with different diameters. bioadhesion in gastrointestinal tract, absorption in gastrointestinal tract, distribution in systemic tissues, and biodegradation in reticuloendothelial system (RES) were studied firstly in detail. The CG microspheres showed different fates in bioadhesion, absorption and distribution according to their diameters, while the biodegradation also varied due to the different locations in RES. These original results would indicate a better way for the CG microspheres in the clinical application. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
所属项目编号20536050 ; 20221603 ; 20636010 ; KJCX2-YW-M02 ; 2007AA09Z439
资助者National Nature Science Foundation of China ; Chinese Academy of Sciences ; 863 HighTech program ; National Nature Science Foundation of China ; Chinese Academy of Sciences ; 863 HighTech program
WOS记录号WOS:000258882200010
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50226
Collection北京大学基础医学院_生物化学与分子生物学系
作者单位1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100080, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wei, Wei,Wang, Lian-Yan,Yuan, Lan,et al. Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2008,69(3):878-886.
APA Wei, Wei,Wang, Lian-Yan,Yuan, Lan,Yang, Xiao-Da,Su, Zhi-Guo,&Ma, Guang-Hui.(2008).Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,69(3),878-886.
MLA Wei, Wei,et al."Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 69.3(2008):878-886.
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