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学科主题口腔医学
Peptide decorated nano-hydroxyapatite with enhanced bioactivity and osteogenic differentiation via polydopamine coating
Sun, Yuhua1; Deng, Yi1,2; Ye, Ziyou2,4; Liang, Shanshan5; Tang, Zhihui3; Wei, Shicheng1,2,3
关键词Nano-hydroxyapatite Peptide Polydopamine Bioactivity Osteogenic Differentiation
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
2013-11-01
DOI10.1016/j.colsurfb.2013.05.037
111页:107-116
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]Biophysics ; Chemistry ; Materials Science
关键词[WOS]MESENCHYMAL STEM-CELLS ; MARROW STROMAL CELLS ; IN-VITRO ; SURFACE MODIFICATION ; BONE ; ADHESION ; FUNCTIONALIZATION ; IMMOBILIZATION ; NANOPARTICLES ; OSTEOBLASTS
英文摘要

To be better used as implant materials in bone graft substitutes, bioactivity and osteogenesis of nanohydroxyapatite (nano-HA) need to be further enhanced. Inspired by adhesive proteins in mussels, here we developed a novel bone forming peptide decorated nano-HA material. In this study, nano-HA was coated by one-step pH-induced polymerization of dopamine, and then the peptide was grafted onto polydopamine (pDA) coated nano-HA (HA-pDA) through catechol chemistry. Our results demonstrated that the peptide-conjugated nano-HA crystals could induce the adhesion and proliferation of MG-63 cells. Moreover, the highly alkaline phosphatase activity of the functionalized nano-HA indicated that the grafted peptide could maintain its biological activity after immobilization onto the surface of HA-pDA, especially at the concentration of 100 mu g/mL. These modified nano-HA crystals with better bioactivity and osteogenic differentiation hold great potential to be applied as bioactive materials in bone repairing, bone regeneration and bio-implant coating applications. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000324897900014
项目编号7132124 ; 2007CB936103
资助机构Beijing Natural Science Foundation ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50227
专题北京大学口腔医学院_口腔颌面外科
北京大学第一临床医学院_血液内科
北京大学口腔医学院_第二门诊部
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Lab Interdisciplinary Studies, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dent Ctr 2, Beijing 100081, Peoples R China
4.Soochow Univ, Sch Biol & Basic Med Sci, Coll Med, Suzhou 215123, Jiangsu, Peoples R China
5.Hainan Med Coll, Sch Stomatol, Dept Oral & Maxillofacial Surg, Hainan 571199, Peoples R China
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GB/T 7714
Sun, Yuhua,Deng, Yi,Ye, Ziyou,et al. Peptide decorated nano-hydroxyapatite with enhanced bioactivity and osteogenic differentiation via polydopamine coating[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2013,111:107-116.
APA Sun, Yuhua,Deng, Yi,Ye, Ziyou,Liang, Shanshan,Tang, Zhihui,&Wei, Shicheng.(2013).Peptide decorated nano-hydroxyapatite with enhanced bioactivity and osteogenic differentiation via polydopamine coating.COLLOIDS AND SURFACES B-BIOINTERFACES,111,107-116.
MLA Sun, Yuhua,et al."Peptide decorated nano-hydroxyapatite with enhanced bioactivity and osteogenic differentiation via polydopamine coating".COLLOIDS AND SURFACES B-BIOINTERFACES 111(2013):107-116.
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