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学科主题口腔医学
Orthodontic Force Induces Systemic Inflammatory Monocyte Responses
Zhou, Y.1,2; Zeng, M.1,2; Kou, X.1,2; Yang, R.1,2; Liu, D.1,2; Wang, X.1,2; Song, Y.1,2; Zhang, J.1; Yan, Y.1,2; Liu, F.1,2; He, D.1,2; Gan, Y.1,3
关键词Osteoclasts Mononuclear Phagocyte System Chemokine Ccl2 Tooth Movement Immune System Inflammation
刊名JOURNAL OF DENTAL RESEARCH
2015-09-01
DOI10.1177/0022034515592868
94期:9页:1295-1302
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者International Science and Technology Cooperation Program of China ; National Natural Science Foundation of China ; International Science and Technology Cooperation Program of China ; National Natural Science Foundation of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]TEMPOROMANDIBULAR-JOINT INFLAMMATION ; HUMAN PERIODONTAL-LIGAMENT ; TOOTH MOVEMENT ; OSTEOCLAST DIFFERENTIATION ; IMMUNE-SYSTEM ; STEM-CELLS ; BONE ; MICE ; OSTEOIMMUNOLOGY ; COMPRESSION
英文摘要

Periodontal inflammation and alveolar bone remodeling during orthodontic tooth movement are considered regional reactions. However, how systemic immune responses are involved in this regional reaction remains unclear. In this study, we explored the systemic effects of orthodontic force by focusing on the mononuclear phagocyte system. Flow cytometric analysis showed that the percentage of inflammatory monocytes, in peripheral blood and in the monocyte reservoir spleen, decreased on days 1 and 3 and then recovered on day 7 after force application. Along with the systemic decrease of inflammatory monocyte percentage, the number of tartrate-resistant acid phosphatase-positive osteoclasts increased in the compression side of the periodontal tissue during orthodontic tooth movement. Systemic transfusion of enhanced green fluorescent protein-labeled inflammatory monocytes showed recruitment of these monocytes to the orthodontic force compression side of periodontal tissues. These monocytes were colocalized with tartrate-resistant acid phosphatase-positive osteoclasts. In vivo and in vitro experiments showed that orthodontic force could upregulate the expression of pivotal monocyte chemokine monocyte chemotactic protein 1 in periodontal tissues or cultured periodontal ligament cells, which may contribute to monocyte recruitment to regional sites. These data suggest that orthodontic force induces systemic immune responses related to inflammatory monocytes and that systemic inflammatory monocytes can be recruited to periodontal tissues by orthodontic force stimulus.

语种英语
所属项目编号2013DFB30360 ; 81470717
资助者International Science and Technology Cooperation Program of China ; National Natural Science Foundation of China ; International Science and Technology Cooperation Program of China ; National Natural Science Foundation of China
WOS记录号WOS:000360188900015
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50228
Collection北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Ctr Craniofacial Stem Cell Res & Regenerat, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Orthodont, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Y.,Zeng, M.,Kou, X.,et al. Orthodontic Force Induces Systemic Inflammatory Monocyte Responses[J]. JOURNAL OF DENTAL RESEARCH,2015,94(9):1295-1302.
APA Zhou, Y..,Zeng, M..,Kou, X..,Yang, R..,Liu, D..,...&Gan, Y..(2015).Orthodontic Force Induces Systemic Inflammatory Monocyte Responses.JOURNAL OF DENTAL RESEARCH,94(9),1295-1302.
MLA Zhou, Y.,et al."Orthodontic Force Induces Systemic Inflammatory Monocyte Responses".JOURNAL OF DENTAL RESEARCH 94.9(2015):1295-1302.
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